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rdf:type |
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lifeskim:mentions |
umls-concept:C0009013,
umls-concept:C0013018,
umls-concept:C0017262,
umls-concept:C0019409,
umls-concept:C0034790,
umls-concept:C0205307,
umls-concept:C0439097,
umls-concept:C0597357,
umls-concept:C1171362,
umls-concept:C1367342,
umls-concept:C1515670,
umls-concept:C1521991,
umls-concept:C1527169,
umls-concept:C1547348,
umls-concept:C1552644,
umls-concept:C1705241,
umls-concept:C1823153,
umls-concept:C2349976
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pubmed:issue |
7
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pubmed:dateCreated |
1989-5-5
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pubmed:abstractText |
We investigated the molecular heterogeneity of gamma delta T-cell antigen receptors (TCR) expressed on T-cell clones generated from peripheral blood lymphocytes of normal donors. Extensive molecular heterogeneity was seen at the gamma-chain level and, to a lesser extent, at the delta-chain level. Both disulfide and non-disulfide gamma delta TCR were found and use different gamma chains with similar molecular masses (range, 41-43 kDa). In contrast, gamma chains of 55-60 kDa, which are expressed on T-cell lines derived from the peripheral blood of patients with immunodeficiency disorders, were not found on T-cell clones derived from the peripheral blood of normal donors. delta chains expressed on these T-cell clones had a molecular mass of 37 kDa and were either disulfide or nondisulfide linked. Significant delta-chain heterogeneity was identified in these clones using the anti-delta TCS1 and the anti-TCR delta 1 monoclonal antibodies. All clones tested were TCR delta 1+, whereas only 25% of the clones were delta TCS1+. The anti-delta TCS1 monoclonal antibody stained and immunoprecipitated both disulfide- and non-disulfide-linked gamma delta TCRs from different T-cell clones from normal donors.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494662-2435832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494662-2438695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494662-2879283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494662-2961573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494662-2969776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494662-2970517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494662-3092224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494662-3095661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494662-3102966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494662-3102967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494662-3102973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494662-3106557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494662-3261778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494662-3458221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494662-3487737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494662-3492555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494662-3672118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494662-3755221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494662-3873654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494662-6334237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494662-6610558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2494662-6974866
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2326-30
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2494662-Antigens, CD8,
pubmed-meshheading:2494662-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:2494662-Antigens, Surface,
pubmed-meshheading:2494662-Cell Line,
pubmed-meshheading:2494662-Cells, Cultured,
pubmed-meshheading:2494662-Clone Cells,
pubmed-meshheading:2494662-Fluorescent Antibody Technique,
pubmed-meshheading:2494662-Humans,
pubmed-meshheading:2494662-Phenotype,
pubmed-meshheading:2494662-Receptors, Antigen, T-Cell,
pubmed-meshheading:2494662-Reference Values,
pubmed-meshheading:2494662-T-Lymphocytes
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pubmed:year |
1989
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pubmed:articleTitle |
Molecular heterogeneity of gamma delta T-cell antigen receptors expressed by CD4- CD8- T-cell clones from normal donors: both disulfide- and non-disulfide-linked receptors are delta TCS1+.
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pubmed:affiliation |
Department of Immunology, University of Texas M. D. Anderson Cancer Center, Houston 77030.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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