Linked Life Data

2494056

Source:http://linkedlifedata.com/resource/pubmed/id/2494056

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-5-5
pubmed:abstractText
The longitudinal follow-up is described of 36 anti-HIV positive haemophiliacs who had seroconverted in the period 1980-82, and of 41 seronegative controls. Laboratory variables were followed up for a mean duration of 2.5 years (1985-87). Of the 36 seropositive patients, AIDS developed in 3, and generalised persistent lymphadenopathy in 9. The HIV-seropositive patient group had lower CD4:CD8 ratios and CD4 counts but higher CD8 counts than the seronegative group. However, there was no deterioration in the values for the lymphocyte subsets during follow-up. Titration on paired sera showed an increase in anti-HIV titre with time. Testing for the presence of HIV antigen was positive in 5 patients, including 2 who later developed AIDS. We conclude that anti-HIV positive haemophiliacs, though actively immunised, often show no symptoms even as long as 7 yr after seroconversion and that, in certain patients, the immune system may even show signs of improvement.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0902-4441
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
254-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Natural history of HIV infection in Swedish haemophiliacs.
pubmed:affiliation
Department for Coagulation Disorders, University of Lund, Malmö, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't