|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1989-3-27
|
|
pubmed:abstractText |
The genetically determined inability to secrete the water-soluble glycoprotein form of the ABO blood group antigens into saliva and other body fluids is a recognized risk factor for meningococcal disease. During a community-wide investigation of a prolonged outbreak of disease due to a B15:P1.16 sulphonamide-resistant strain of Neisseria meningitidis in Stonehouse, Gloucestershire (the Stonehouse survey), the ABO blood group and secretor status of almost 5000 residents was determined. The proportion of non-secretors in the Stonehouse population was significantly higher than the proportion of non-secretors among blood donors in the South West Region and in England generally. Seven of 13 Stonehouse residents with meningococcal disease who were tested were found to be non-secretors, a high proportion. The outbreak in Stonehouse cannot be explained solely in terms of the increased proportion of non-secretors. There was no clear correlation between the proportions of non-secretors in different areas within the town and the incidence of cases of meningococcal disease. Carriers of meningococci, whether outbreak or other strains, were not more likely to be non-secretors. The reasons why non-secretors are more susceptible to meningococcal disease remain to be determined, but they do not appear to be related to carriage of meningococci.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0950-2688
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
102
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1-10
|
|
pubmed:dateRevised |
2010-9-7
|
|
pubmed:meshHeading |
pubmed-meshheading:2492943-ABO Blood-Group System,
pubmed-meshheading:2492943-Adolescent,
pubmed-meshheading:2492943-Adult,
pubmed-meshheading:2492943-Aged,
pubmed-meshheading:2492943-Carrier State,
pubmed-meshheading:2492943-Child,
pubmed-meshheading:2492943-Child, Preschool,
pubmed-meshheading:2492943-Disease Outbreaks,
pubmed-meshheading:2492943-England,
pubmed-meshheading:2492943-Humans,
pubmed-meshheading:2492943-Infant,
pubmed-meshheading:2492943-Isoantigens,
pubmed-meshheading:2492943-Lewis Blood-Group System,
pubmed-meshheading:2492943-Meningitis, Meningococcal,
pubmed-meshheading:2492943-Middle Aged,
pubmed-meshheading:2492943-Neisseria meningitidis,
pubmed-meshheading:2492943-Saliva,
pubmed-meshheading:2492943-Socioeconomic Factors
|
|
pubmed:year |
1989
|
|
pubmed:articleTitle |
The Stonehouse study: secretor status and carriage of Neisseria species.
|
|
pubmed:affiliation |
Department of Bacteriology, University of Edinburgh.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
