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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1989-3-9
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pubmed:abstractText |
The efficacy of continuous and intermittent nitroglycerin patches (10 mg/day) was compared in a randomized, placebo-controlled trial in 36 patients with stable angina and reproducible, exercise-induced ST depression. Intermittent treatment was administered either 18 or 14 h/day with an intermission of 6 h or 10 h, respectively. Exercise tests were performed during the last 2 h of patch application. Compared with placebo, neither continuous nitroglycerin nor the two intermittent regimens prolonged total treadmill time or time to 1 mm ST depression. No treatment eliminated exercise-induced ST depression in greater than 1 of the 36 patients. Time to angina was prolonged (by 40 +/- 66 s) only during the "10 h off" treatment (p = 0.001); time to angina increased by greater than or equal to 20% in 13 patients. Responders to treatment could be predicted by a short history of angina (p less than 0.05) and a time to angina less than or equal to 250 s during the placebo test. For each treatment, greater than or equal to 25 of the patients reported headache; 4 additional patients dropped out because of severe headache and 2 others because of a coronary event in a washout period. Thus, in most patients with stable angina, side effects outweight any benefit demonstrable with this therapy.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
|
pubmed:issn |
0735-1097
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
13
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
421-5
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:2492322-Administration, Cutaneous,
pubmed-meshheading:2492322-Adult,
pubmed-meshheading:2492322-Aged,
pubmed-meshheading:2492322-Angina Pectoris,
pubmed-meshheading:2492322-Electrocardiography,
pubmed-meshheading:2492322-Exercise Test,
pubmed-meshheading:2492322-Female,
pubmed-meshheading:2492322-Headache,
pubmed-meshheading:2492322-Humans,
pubmed-meshheading:2492322-Male,
pubmed-meshheading:2492322-Middle Aged,
pubmed-meshheading:2492322-Nitroglycerin
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pubmed:year |
1989
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pubmed:articleTitle |
Limited usefulness of intermittent nitroglycerin patches in stable angina.
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pubmed:affiliation |
Department of Medicine, Montreal Heart Institute, Quebec, Canada.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|