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rdf:type |
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lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0018557,
umls-concept:C0019647,
umls-concept:C0029005,
umls-concept:C0086860,
umls-concept:C0178539,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C1426975,
umls-concept:C1521761,
umls-concept:C1552599,
umls-concept:C1704675,
umls-concept:C1704787
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pubmed:issue |
2
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pubmed:dateCreated |
1989-2-21
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pubmed:abstractText |
The promoter region of a replication-dependent histone H3.2 gene contains a putative DNA binding site for the Jun oncoprotein within a 32-nucleotide regulatory domain. The hamster sequence differs by one nucleotide from the AP-1 consensus sequence found in several promoters responsive to phorbol 12-myristate 13-acetate. We have identified the factors interacting with this region as 42- and 45-kDa proteins by DNA affinity chromatography, immunoblotting, and UV crosslinking. These proteins, which are candidates for conferring high-level expression to the histone promoter, share an antigenic epitope with the DNA-binding domain of Jun but diverge from it at the amino terminus. The interaction of these proteins with the promoter of a replication-dependent cellular gene provides evidence that members of the Jun oncoprotein family may play specific roles in the expression of genes essential for progression of the cell cycle.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2492109-2457172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2492109-2822255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2492109-2825349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2492109-2830989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2492109-2836064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2492109-2900470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2492109-3023878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2492109-3034432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2492109-3034433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2492109-3040261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2492109-3130660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2492109-3136397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2492109-3336354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2492109-3347253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2492109-3422745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2492109-3469660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2492109-3532321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2492109-3627229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2492109-3677172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2492109-3685975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2492109-3708685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2492109-4059922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2492109-6513920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2492109-6707023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2492109-6933441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2492109-7053561
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
491-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2492109-Animals,
pubmed-meshheading:2492109-Antibodies,
pubmed-meshheading:2492109-Base Sequence,
pubmed-meshheading:2492109-Chromatography, Affinity,
pubmed-meshheading:2492109-Cricetinae,
pubmed-meshheading:2492109-Cross Reactions,
pubmed-meshheading:2492109-DNA,
pubmed-meshheading:2492109-DNA Probes,
pubmed-meshheading:2492109-DNA Replication,
pubmed-meshheading:2492109-Deoxyribonuclease I,
pubmed-meshheading:2492109-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:2492109-Histones,
pubmed-meshheading:2492109-Immunoblotting,
pubmed-meshheading:2492109-Molecular Sequence Data,
pubmed-meshheading:2492109-Oncogene Protein p65(gag-jun),
pubmed-meshheading:2492109-Promoter Regions, Genetic,
pubmed-meshheading:2492109-Retroviridae Proteins,
pubmed-meshheading:2492109-Transcription Factors
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pubmed:year |
1989
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pubmed:articleTitle |
Interaction of cellular factors related to the Jun oncoprotein with the promoter of a replication-dependent hamster histone H3.2 gene.
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pubmed:affiliation |
Department of Biochemistry, University of Southern California School of Medicine, Los Angeles 90033.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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