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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
1991-10-21
|
| pubmed:abstractText |
TSH receptor antibodies and peripheral blood lymphocyte subsets have been measured in fourteen patients with untreated Graves' thyrotoxicosis. CD8 (suppressor) cells were reduced (p less than 0.01) and helper/suppressor cell ratio was increased in Graves' patients. Increased levels of 4F2 positive (activated) T cells were found in the patients compared to controls (p less than 0.001) and there was a negative correlation between 4F2 positive cells and TSH receptor antibodies (TBII). It may be possible, with multiple immunological markers, to identify different stages in the pathogenesis of autoimmune thyroid disease.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0891-6934
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
4
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
103-7
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2491637-Adolescent,
pubmed-meshheading:2491637-Adult,
pubmed-meshheading:2491637-Aged,
pubmed-meshheading:2491637-Antibodies, Monoclonal,
pubmed-meshheading:2491637-Autoantibodies,
pubmed-meshheading:2491637-Biological Markers,
pubmed-meshheading:2491637-Female,
pubmed-meshheading:2491637-Graves Disease,
pubmed-meshheading:2491637-Humans,
pubmed-meshheading:2491637-Lymphocyte Activation,
pubmed-meshheading:2491637-Male,
pubmed-meshheading:2491637-Middle Aged,
pubmed-meshheading:2491637-Receptors, Thyrotropin,
pubmed-meshheading:2491637-T-Lymphocyte Subsets
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Inverse correlation between activated T cells and TSH receptor antibodies in Graves' disease.
|
| pubmed:affiliation |
Clinical Sciences Centre, Northern General Hospital, Sheffield.
|
| pubmed:publicationType |
Journal Article
|