Linked Life Data

2487676

Source:http://linkedlifedata.com/resource/pubmed/id/2487676

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-3-22
pubmed:abstractText
A T cell specific cDNA clone, YT15, has been isolated using the technique of subtractive hybridization. This gene is expressed predominantly in thymocytes and encodes a newly identified intracytoplasmic protein specific for T cells, since neither the nucleotide sequence of the cDNA clone nor the deduced amino acid sequence has significant homology to sequences in the GenBank or NBRF databases. The level of transcription of this gene in human leukemic cell line, Jurkat, can be reduced by stimulation of the T cell receptor CD3 (TcR-T3) complex. In addition, the levels of these messages are also greatly enhanced in some TcR/T3 receptor mutants. These findings suggest that this gene product may be involved in a T cell activation pathway within the cell.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0953-8178
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
59-65
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Isolation of a T cell specific cDNA clone possibly involved in the T cell activation pathway.
pubmed:affiliation
Ontario Cancer Institute, Toronto, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't