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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1991-3-26
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pubmed:abstractText |
1. Matching shows a positive effect, even in the CsA era. In this report we have seen that in a group of 12,886 patients (90% of whom were given CsA), when a donor and recipient had no A,B,DR mismatches, their overall survival exceeded baseline by 5% at 6 months and by a 2.5-year increase in half-life past 6 months. 2. When loci are combined, their effect on graft survival is greater than when loci are viewed individually. Differences from baseline in Figures 6-13 are greater than those in Figures 2-5. 3. Class II DR antigens show a short-term effect but relatively little long-term differences, whereas Class I antigens (A and B loci) have immaterial short-term effects but significant long-term differences. Comparisons involving DR mismatches (eg, Figures 5, 10, 11, 12) always showed significant differences in short-term survival (an average 9% increase from best to worst mismatch categories), but, when DR was studied alone (Fig. 5), small differences in half-lives between 0, 1, and 2 mismatches were noted (ie, 7.6 years vs 6.0 years). In contrast, when A and B mismatches were studied without DR (eg, Figs. 2, 3, 6-9), 6-month graft survivals were never significantly different from baseline, whereas nearly all comparisons (Figs. 2, 3, 6-12) showed significantly widening half-life differences (approximately 4 years) between best and worst mismatch.(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0890-9016
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
353-60
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:2487603-Adult,
pubmed-meshheading:2487603-Graft Survival,
pubmed-meshheading:2487603-HLA Antigens,
pubmed-meshheading:2487603-HLA-A Antigens,
pubmed-meshheading:2487603-HLA-B Antigens,
pubmed-meshheading:2487603-HLA-DR Antigens,
pubmed-meshheading:2487603-Humans,
pubmed-meshheading:2487603-Kidney Transplantation,
pubmed-meshheading:2487603-Registries,
pubmed-meshheading:2487603-Time Factors
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pubmed:year |
1989
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pubmed:articleTitle |
Short- and long-term effects of HLA matching.
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pubmed:publicationType |
Journal Article
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