Linked Life Data

2485679

Source:http://linkedlifedata.com/resource/pubmed/id/2485679

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1990-12-13
pubmed:abstractText
The kinetics of appearance of immunoglobulins (Ig) IgA, IgM, IgG1, and IgG2a were studied immunocytochemically at the ocular surface of Swiss-Webster mice of select ages. Immunostaining for IgA was first detectable at the corneal surface of 21 postnatal day (P) old mice. By 25 P, IgM also was present and by 30 P. IgG1 and IgG2a immunostaining was observed. No change in immunostaining was seen in one year old (365 P) animals when compared with 37 P aged mice. IgA staining was always of greater intensity than IgM, IgG1, or IgG2a. These immunocytochemical data were compared with Ig levels in pooled serum from similarly aged mice using serial radial immunodiffusion (SRID). IgA was not detected in serum until mice were 25 P; IgM at 15 P; and both IgG1 and IgG2a (presumably maternal) at 5 P. No correlation between the time of appearance of serum levels of Igs and ocular surface immunostaining was seen for any of the Igs. These studies establish the time sequence of Ig appearance at the eye surface and suggest that the source of these Igs is not the serum.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0896-0623
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
294-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Kinetics of immunoglobulin appearance at the ocular surface.
pubmed:affiliation
Department of Anatomy/Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201.
pubmed:publicationType
Journal Article, Comparative Study