| pubmed-article:2485079 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2485079 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:2485079 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2485079 | lifeskim:mentions | umls-concept:C2697656 | lld:lifeskim |
| pubmed-article:2485079 | lifeskim:mentions | umls-concept:C0175697 | lld:lifeskim |
| pubmed-article:2485079 | lifeskim:mentions | umls-concept:C0014072 | lld:lifeskim |
| pubmed-article:2485079 | lifeskim:mentions | umls-concept:C0023810 | lld:lifeskim |
| pubmed-article:2485079 | lifeskim:mentions | umls-concept:C0376518 | lld:lifeskim |
| pubmed-article:2485079 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2485079 | pubmed:dateCreated | 1991-10-21 | lld:pubmed |
| pubmed-article:2485079 | pubmed:abstractText | Adoptive transfer of experimental allergic encephalomyelitis (EAE) is enhanced after in vitro culture of myelin basic protein (BP)-sensitized lymphoid cells with BP. Addition of lipopolysaccharide (LPS) to the culture further augments transfer of EAE to a level 5 times greater than that achieved with cells activated only with BP. Neither the proliferative response of a BP-specific cell line nor the production of IL-2 by BP-sensitized lymphoid cells in response to BP was augmented by the addition of LPS to the culture. Augmentation of EAE was also observed if recipients received simultaneous injections of BP-sensitized lymph node cells (BP/LNC) cultured with BP (BP-activated) and normal spleen cells cultured independently with LPS (LPS/Spl-C). To analyze the effect of contact between these two cell populations in vivo, we mixed the two cell populations in vitro at reduced cell concentrations. When BP-activated BP-LNC were mixed with LPS-Spl-C in vitro, a marked synergistic proliferative response was observed. Irradiation of BP-activated BP/LNC abrogated this synergistic response, whereas irradiation of LPS/Spl-C did not, suggesting that the proliferating population was in the BP/LNC and that the LPS/Spl-C enhanced their proliferation. These results indicate that LPS exerts its effect through BP-nonspecific cells and that these cells enhance transfer of EAE by augmenting the proliferation of the BP-specific cells in vivo after transfer. | lld:pubmed |
| pubmed-article:2485079 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2485079 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2485079 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2485079 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2485079 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2485079 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2485079 | pubmed:issn | 0891-6934 | lld:pubmed |
| pubmed-article:2485079 | pubmed:author | pubmed-author:HamadaTT | lld:pubmed |
| pubmed-article:2485079 | pubmed:author | pubmed-author:AlvordE CECJr | lld:pubmed |
| pubmed-article:2485079 | pubmed:author | pubmed-author:KiesM WMW | lld:pubmed |
| pubmed-article:2485079 | pubmed:author | pubmed-author:DriscollB FBF | lld:pubmed |
| pubmed-article:2485079 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2485079 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:2485079 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2485079 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2485079 | pubmed:pagination | 275-84 | lld:pubmed |
| pubmed-article:2485079 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2485079 | pubmed:meshHeading | pubmed-meshheading:2485079-... | lld:pubmed |
| pubmed-article:2485079 | pubmed:meshHeading | pubmed-meshheading:2485079-... | lld:pubmed |
| pubmed-article:2485079 | pubmed:meshHeading | pubmed-meshheading:2485079-... | lld:pubmed |
| pubmed-article:2485079 | pubmed:meshHeading | pubmed-meshheading:2485079-... | lld:pubmed |
| pubmed-article:2485079 | pubmed:meshHeading | pubmed-meshheading:2485079-... | lld:pubmed |
| pubmed-article:2485079 | pubmed:meshHeading | pubmed-meshheading:2485079-... | lld:pubmed |
| pubmed-article:2485079 | pubmed:meshHeading | pubmed-meshheading:2485079-... | lld:pubmed |
| pubmed-article:2485079 | pubmed:meshHeading | pubmed-meshheading:2485079-... | lld:pubmed |
| pubmed-article:2485079 | pubmed:meshHeading | pubmed-meshheading:2485079-... | lld:pubmed |
| pubmed-article:2485079 | pubmed:meshHeading | pubmed-meshheading:2485079-... | lld:pubmed |
| pubmed-article:2485079 | pubmed:meshHeading | pubmed-meshheading:2485079-... | lld:pubmed |
| pubmed-article:2485079 | pubmed:meshHeading | pubmed-meshheading:2485079-... | lld:pubmed |
| pubmed-article:2485079 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2485079 | pubmed:articleTitle | LPS augments adoptive transfer of experimental allergic encephalomyelitis in the Lewis rat. | lld:pubmed |
| pubmed-article:2485079 | pubmed:affiliation | Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, MD 20892. | lld:pubmed |
| pubmed-article:2485079 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2485079 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2485079 | lld:pubmed |
