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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1991-10-1
|
| pubmed:abstractText |
Enalapril (MK-421), a new angiotensin converting enzyme inhibitor, reduces the blood pressure in one-kidney, one-clip hypertensive rats at 30 mg/kg p.o. (n = 12). On the fifth day and during the fifth week after renal artery constriction, systolic blood pressure decreased from 196 +/- 4 and 240 +/- 5 mm Hg pretreatment to 159 +/- 8 and 225 +/- 3 mm Hg, respectively (p less than 0.001 and 0.05, respectively) and was maintained at this level for about 8 h. Serum angiotensin converting enzyme activity was significantly inhibited by enalapril. Similarly, enalapril (30 mg/kg p.o.) in two-kidney, one-clip hypertensive rats (n = 18) on the fifth day and during the fifth week after operation resulted in a decrease in blood pressure from 162 +/- 5 and 217 +/- 5 mm Hg to 117 +/- 6 and 120 +/- 7 mm Hg, respectively, to the preoperative normotensive level (113 +/- 1 mm Hg). These results indicate that the renin-angiotensin system may play an important role in the pathogenesis of two-kidney, one-clip hypertensive rats. However, in the pathogenesis of one-kidney, one-clip hypertensive rats, other mechanisms seem to be involved besides the renin-angiotensin system.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0160-2446
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
10 Suppl 7
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
S119-21
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| pubmed:dateRevised |
2003-11-14
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| pubmed:meshHeading | |
| pubmed:year |
1987
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| pubmed:articleTitle |
Blood pressure response of two types of Goldblatt hypertensive rats to enalapril.
|
| pubmed:affiliation |
Shanghai Institute of Hypertension, People's Republic of China.
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| pubmed:publicationType |
Journal Article
|