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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2-3
|
| pubmed:dateCreated |
1990-5-9
|
| pubmed:abstractText |
Xenografts of human osteosarcoma growing in athymic mice are inhibited in growth rate by human interferon-alpha (IFN-alpha) treatment. In addition, differentiation of trabecular bone occurs external to the osteosarcomatous tissue and this is entirely dependent on IFN treatment. We have used species-specific anticollagens and antivimentin antibodies to determine the species origins of this trabecular bone. By using immunohistochemical procedures, it was found that this bone is host-derived. These results suggest that IFN provoked the production of a bone-inducing agent by the human osteosarcomas.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0300-8207
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
23
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
145-51
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2483537-Animals,
pubmed-meshheading:2483537-Collagen,
pubmed-meshheading:2483537-Female,
pubmed-meshheading:2483537-Immunohistochemistry,
pubmed-meshheading:2483537-Interferons,
pubmed-meshheading:2483537-Mice,
pubmed-meshheading:2483537-Mice, Inbred BALB C,
pubmed-meshheading:2483537-Mice, Nude,
pubmed-meshheading:2483537-Osteogenesis,
pubmed-meshheading:2483537-Osteosarcoma,
pubmed-meshheading:2483537-Species Specificity,
pubmed-meshheading:2483537-Tumor Cells, Cultured
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Interferon effects on osteoinduction.
|
| pubmed:affiliation |
Nuffield Department of Orthopaedic Surgery, University of Oxford, UK.
|
| pubmed:publicationType |
Journal Article
|