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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1990-3-21
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pubmed:abstractText |
Mouse c-myb has been implicated in the regulation of differentiation and proliferation of haematopoietic cells. Analysis of the chromatin structure of the promoter region of c-myb in embryonal carcinoma (EC) cells and embryonal stem (ES) cells reveals a DNAse I-hypersensitive site coincident with a site found in c-myb-expressing haematopoietic cells, but absent in murine fibroblasts (which do not express c-myb). EC and ES cells were found to express c-myb mRNA, albeit at a level lower than found in haematopoietic cells. Differentiation of ES cells into embryoid bodies resulted in an elevated level of c-myb expression.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0301-4681
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
24-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2482820-Animals,
pubmed-meshheading:2482820-Deoxyribonuclease I,
pubmed-meshheading:2482820-Embryonal Carcinoma Stem Cells,
pubmed-meshheading:2482820-Gene Expression,
pubmed-meshheading:2482820-Hematopoiesis,
pubmed-meshheading:2482820-Mice,
pubmed-meshheading:2482820-Neoplasms, Germ Cell and Embryonal,
pubmed-meshheading:2482820-Neoplastic Stem Cells,
pubmed-meshheading:2482820-Proto-Oncogene Proteins,
pubmed-meshheading:2482820-Proto-Oncogene Proteins c-myb,
pubmed-meshheading:2482820-RNA,
pubmed-meshheading:2482820-Transcription, Genetic,
pubmed-meshheading:2482820-Tumor Cells, Cultured
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pubmed:year |
1989
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pubmed:articleTitle |
Expression of c-myb in embryonal carcinoma cells and embryonal stem cells.
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pubmed:affiliation |
Department of Genetics, University of Cambridge, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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