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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1990-3-26
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pubmed:abstractText |
T lymphocytes from rats with malignant fibrous histiocytoma at different stages of tumor growth were investigated for sensitization to bovine myelin basic protein (MBP). The immunological reactivity was assessed by a leukocyte adherence inhibition assay as an in vitro correlate of cellular immunity. We found that only T lymphocytes obtained 4 and 6 days after tumor transplantation are reactive to MBP (1-2 micrograms/ml). Since the sequence of the antigenic determinants from MBP is known, our findings may make it possible to select synthetic epitopes for generating cytotoxic T lymphocytes to these tumor cells.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0100-879X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
721-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2482789-Animals,
pubmed-meshheading:2482789-Histiocytoma, Benign Fibrous,
pubmed-meshheading:2482789-Immunity, Cellular,
pubmed-meshheading:2482789-Leukocyte Adherence Inhibition Test,
pubmed-meshheading:2482789-Myelin Basic Proteins,
pubmed-meshheading:2482789-Neoplasm Transplantation,
pubmed-meshheading:2482789-Rats,
pubmed-meshheading:2482789-Rats, Inbred Strains,
pubmed-meshheading:2482789-T-Lymphocytes
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pubmed:year |
1989
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pubmed:articleTitle |
Cellular immunity to bovine myelin basic protein in rats bearing malignant fibrous histiocytoma.
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pubmed:affiliation |
Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceara, Fortaleza, CE, Brasil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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