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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1990-3-2
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pubmed:abstractText |
Monoclonal antibodies directed against the 51 kD merozoite surface antigen of Plasmodium falciparum also bind to other antigens within the infected cell. The sizes of these cross-reacting antigens have been characterized. Immunofluorescence due to the reaction of one of the monoclonal antibodies with these cross-reacting antigens was localized in the intra-erythrocytic parasite and in granules in the infected red cell cytoplasm. This immunofluorescence could be distinguished from the merozoite surface antigen in parasite lines with a variant serotype of the merozoite surface antigen which fails to react with the monoclonal antibodies. It was found that the in-vitro growth inhibition caused by the presence of one of the monoclonal antibodies, 8G10/48, was dependent on the expression of the corresponding serotype of merozoite surface antigen, a finding consistent with the inhibitory effect of this antibody being primarily directed against the merozoite surface antigen and not the cross-reacting antigens. Analysis of the frequency at which epitopes occur suggests that such cross-reacting proteins will be commonly seen in malaria, without the need to postulate a selective advantage for such cross-reacting specificities.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Protozoan,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Protozoan,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxanthines
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0141-9838
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
593-601
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2482473-Animals,
pubmed-meshheading:2482473-Antibodies, Monoclonal,
pubmed-meshheading:2482473-Antibodies, Protozoan,
pubmed-meshheading:2482473-Antigens, Protozoan,
pubmed-meshheading:2482473-Antigens, Surface,
pubmed-meshheading:2482473-Cross Reactions,
pubmed-meshheading:2482473-Epitopes,
pubmed-meshheading:2482473-Fluorescent Antibody Technique,
pubmed-meshheading:2482473-Hypoxanthines,
pubmed-meshheading:2482473-Immunoblotting,
pubmed-meshheading:2482473-Plasmodium falciparum
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pubmed:year |
1989
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pubmed:articleTitle |
Cross-reactivity of antibody against an epitope of the Plasmodium falciparum second merozoite surface antigen.
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pubmed:affiliation |
Queensland Institute of Medical Research, Brisbane, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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