| pubmed-article:2482404 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2482404 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:2482404 | lifeskim:mentions | umls-concept:C0002210 | lld:lifeskim |
| pubmed-article:2482404 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:2482404 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:2482404 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:2482404 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:2482404 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2482404 | pubmed:dateCreated | 1990-3-9 | lld:pubmed |
| pubmed-article:2482404 | pubmed:abstractText | The synthesis of alpha-fetoprotein in primary cultures of adult mouse hepatocytes was studied under different conditions of cultivation. On dried collagen, the majority of cells resumed synthesis of alpha-fetoprotein. Alpha-fetoprotein re-expression was accompanied by the flattening of hepatocytes, loss of gap junctional communication and domain-specific membrane antigens, and by alteration of actin pattern. Cultivation of hepatocytes on polymerized collagen gel did not prevent the re-expression of alpha-fetoprotein and other alterations described above. Hepatocyte cultivation within three-dimensional collagen gel as well as co-cultivation of hepatocytes with liver epithelial cells IAR-20 led to re-establishment of organotypic trabeculae-like structures consisting of polygonal hepatocytes with normal pattern of actin, membrane antigens and cell-cell communication. These structures were almost alpha-fetoprotein-negative. It is suggested that hepatocyte shape is co-ordinately regulated with the switch from an adult "block" of hepatocyte functions to an embryonic one. Three-dimensional extracellular matrix may in turn, influence the maintenance of hepatocyte shape. | lld:pubmed |
| pubmed-article:2482404 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2482404 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2482404 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2482404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2482404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2482404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2482404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2482404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2482404 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2482404 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2482404 | pubmed:issn | 0735-1313 | lld:pubmed |
| pubmed-article:2482404 | pubmed:author | pubmed-author:AbelevG IGI | lld:pubmed |
| pubmed-article:2482404 | pubmed:author | pubmed-author:GleibermanA... | lld:pubmed |
| pubmed-article:2482404 | pubmed:author | pubmed-author:Sharovskaya... | lld:pubmed |
| pubmed-article:2482404 | pubmed:author | pubmed-author:KudrjavtsevaE... | lld:pubmed |
| pubmed-article:2482404 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2482404 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:2482404 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2482404 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2482404 | pubmed:pagination | 95-107 | lld:pubmed |
| pubmed-article:2482404 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:2482404 | pubmed:meshHeading | pubmed-meshheading:2482404-... | lld:pubmed |
| pubmed-article:2482404 | pubmed:meshHeading | pubmed-meshheading:2482404-... | lld:pubmed |
| pubmed-article:2482404 | pubmed:meshHeading | pubmed-meshheading:2482404-... | lld:pubmed |
| pubmed-article:2482404 | pubmed:meshHeading | pubmed-meshheading:2482404-... | lld:pubmed |
| pubmed-article:2482404 | pubmed:meshHeading | pubmed-meshheading:2482404-... | lld:pubmed |
| pubmed-article:2482404 | pubmed:meshHeading | pubmed-meshheading:2482404-... | lld:pubmed |
| pubmed-article:2482404 | pubmed:meshHeading | pubmed-meshheading:2482404-... | lld:pubmed |
| pubmed-article:2482404 | pubmed:meshHeading | pubmed-meshheading:2482404-... | lld:pubmed |
| pubmed-article:2482404 | pubmed:meshHeading | pubmed-meshheading:2482404-... | lld:pubmed |
| pubmed-article:2482404 | pubmed:meshHeading | pubmed-meshheading:2482404-... | lld:pubmed |
| pubmed-article:2482404 | pubmed:meshHeading | pubmed-meshheading:2482404-... | lld:pubmed |
| pubmed-article:2482404 | pubmed:meshHeading | pubmed-meshheading:2482404-... | lld:pubmed |
| pubmed-article:2482404 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2482404 | pubmed:articleTitle | Synthesis of alpha-fetoprotein in hepatocytes is co-ordinately regulated with cell-cell and cell-matrix interactions. | lld:pubmed |
| pubmed-article:2482404 | pubmed:affiliation | All-Union Cancer Research Centre, Moscow, USSR. | lld:pubmed |
| pubmed-article:2482404 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2482404 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2482404 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2482404 | lld:pubmed |
