Linked Life Data

2481538

Source:http://linkedlifedata.com/resource/pubmed/id/2481538

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1990-2-21
pubmed:abstractText
It is noteworthy that the beginnings of research on idiotypy in humans have used immunohematological assay systems; Kunkel and coworkers have succeeded in localising idiotypic determinants on Fab fragments of anti Rh(D)-antibodies over 15 years ago. The present contribution follows up on literature devoted to analysis of the significance for idiotypy in immunohaematology. Investigation into idiotypic properties of immunoglobulins is rewarding for both, the exploring scientist and for patient management in autoimmunity and organ transplantation. It appears that autoimmune attack towards such autoantigens as clotting factor VIII and fibrinogen may be downregulated through development of anti-idiotypic antibodies that bind and may block the primary autoantibody. Conversely, post-transfusion and post-transplantation periods in recipients are often followed by development of anti-idiotypic anti-alloantibodies with immunoregulatory (suppressive or enhancing) capacities. This review sets out to analyse the involvement known so far of idiotypic regulatory mechanisms in immunohaematology.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1011-6974
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
185-92
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
[Significance of idiotype characteristics in immune hematology].
pubmed:affiliation
Abteilung für Transfusionsmedizin, Hämatologisches Zentrallabor der Universität, Inselspital Bern.
pubmed:publicationType
Journal Article, English Abstract, Review, Research Support, Non-U.S. Gov't