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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1990-2-6
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pubmed:abstractText |
The lower brain 5-hydroxytryptamine concentration in alcohol-preferring C57BL, compared with -non-preferring CBA, mice is caused by a decrease in circulating tryptophan availability to the brain secondarily to a higher liver tryptophan pyrrolase activity associated with a higher circulating corticosterone concentration. Activity or expression of liver tryptophan pyrrolase and/or their induction by glucocorticoids may be important biological determinants of predisposition to alcohol consumption.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2481450-1212203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2481450-14183213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2481450-21336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2481450-2431698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2481450-2435302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2481450-2437596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2481450-2864234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2481450-2874817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2481450-290764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2481450-3007443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2481450-307698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2481450-3219191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2481450-3469057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2481450-3498133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2481450-3628446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2481450-4371899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2481450-4384954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2481450-4403641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2481450-446865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2481450-5472211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2481450-5581909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2481450-6270470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2481450-6540585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2481450-6593754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2481450-962891
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
264
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
597-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2481450-Alcoholism,
pubmed-meshheading:2481450-Animals,
pubmed-meshheading:2481450-Brain,
pubmed-meshheading:2481450-Disease Models, Animal,
pubmed-meshheading:2481450-Homeostasis,
pubmed-meshheading:2481450-Hydroxyindoleacetic Acid,
pubmed-meshheading:2481450-Liver,
pubmed-meshheading:2481450-Male,
pubmed-meshheading:2481450-Mice,
pubmed-meshheading:2481450-Mice, Inbred C57BL,
pubmed-meshheading:2481450-Mice, Inbred CBA,
pubmed-meshheading:2481450-Reference Values,
pubmed-meshheading:2481450-Serotonin,
pubmed-meshheading:2481450-Tryptophan,
pubmed-meshheading:2481450-Tryptophan Oxygenase
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pubmed:year |
1989
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pubmed:articleTitle |
Liver tryptophan pyrrolase. A major determinant of the lower brain 5-hydroxytryptamine concentration in alcohol-preferring C57BL mice.
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pubmed:affiliation |
Biomedical Research Laboratory, Whitchurch Hospital, Cardiff, Wales, U.K.
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pubmed:publicationType |
Journal Article
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