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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3 Suppl
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pubmed:dateCreated |
1990-1-23
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pubmed:abstractText |
We have examined serum alpha-fetoprotein (AFP) concentrations in the pre- and post-orthotopic liver transplantation (OLT) period of a population of 19 adult patients. (Five with secondary hepatic malignancy and fourteen with primary hepatic cancer). In pre-OLT, rises in serum AFP levels are indicatives for hepatocellular carcinoma (HCC): six of our nine cases of HCC were associated with the increase in serum AFP concentration, but none of the non-hepatocellular primary cancers and only one of the five secondary malignancy (hepatic metastasis of breast carcinoma with serum AFP values around 20 ng/ml). In pre-OLT, AFP values correlated with viable tumor mass rather than tumor:volume. In post-OLT, rises in AFP concentrations may be explained either by recurrent hepatic cancer or by hepatic post-necrotic regeneration. In this case, the increase in serum transaminasis is an important help for differential diagnosis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0392-0208
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
132-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2480413-Humans,
pubmed-meshheading:2480413-Liver Diseases,
pubmed-meshheading:2480413-Liver Neoplasms,
pubmed-meshheading:2480413-Liver Regeneration,
pubmed-meshheading:2480413-Liver Transplantation,
pubmed-meshheading:2480413-Monitoring, Physiologic,
pubmed-meshheading:2480413-Neoplasm Recurrence, Local,
pubmed-meshheading:2480413-Tumor Markers, Biological,
pubmed-meshheading:2480413-alpha-Fetoproteins
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pubmed:articleTitle |
Role of serum alpha-fetoprotein in pre- and post-orthotopic liver transplantation (OLT) for malignant disease.
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pubmed:publicationType |
Journal Article,
Comparative Study
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