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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
1990-1-19
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pubmed:abstractText |
IL-6 (formerly PCTGF, HP-1, BSF-2, HGF, IFN-beta 2, 26 kDa) is a recently defined lymphokine demonstrating activity on multiple cell types, including hepatocytes, thymocytes, T cells, plasmacytomas, and B cells. The biologic effects of IL-6 on lymphocytes, particularly B cells, suggest this factor may be involved in the regulation of normal immune responses. Accordingly, we have investigated the role of IL-6 in Ag-specific responses of B cells from both naive and Ag-primed mice. When Ag-primed splenic T cells were used as a source of help, naive (primary) B cell responses specific for the hemagglutinin molecule of the influenza A virus (PR8) were fully inhibited by the addition of an anti-IL-6 antiserum, and are thus IL-6 dependent. In contrast, secondary B cell responses were essentially IL-6 independent, being unaffected by this antiserum even at concentrations 10-fold higher than required to completely inhibit primary responses. This differential IL-6 requirement was further investigated by using a panel of hemagglutinin molecule-specific Th clones. Consistent with the above findings, a Th1 clone secreting biologically active IL-6 enables antibody secretion by both primary and secondary B cells, whereas Th1 clones that do not produce IL-6 support secondary responses, but fail to help primary B cell responses unless exogenous IL-6 is added. These results provide the first instance of differential lymphokine requirements among primary vs secondary B cell responses, and suggest T cell-derived IL-6 plays a critical role during the regulation of humoral immune responses. Moreover, functionally distinct Th1 clones were identified that differed in IL-6 secretion and their corresponding ability to induce Ig secretion by primary and secondary B cells.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
143
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4019-24
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2480384-Animals,
pubmed-meshheading:2480384-Antibodies, Viral,
pubmed-meshheading:2480384-B-Lymphocytes,
pubmed-meshheading:2480384-Clone Cells,
pubmed-meshheading:2480384-Epitopes,
pubmed-meshheading:2480384-Immunologic Memory,
pubmed-meshheading:2480384-Influenza A virus,
pubmed-meshheading:2480384-Interleukin-6,
pubmed-meshheading:2480384-Male,
pubmed-meshheading:2480384-Mice,
pubmed-meshheading:2480384-Mice, Inbred BALB C,
pubmed-meshheading:2480384-Mice, Inbred DBA,
pubmed-meshheading:2480384-Plasma Cells,
pubmed-meshheading:2480384-T-Lymphocytes, Helper-Inducer
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pubmed:year |
1989
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pubmed:articleTitle |
T cell derived IL-6 is differentially required for antigen-specific antibody secretion by primary and secondary B cells.
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pubmed:affiliation |
National Cancer Institute, Laboratory of Genetics, Bethesda, MD 20892.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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