| pubmed-article:2480380 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2480380 | lifeskim:mentions | umls-concept:C0021759 | lld:lifeskim |
| pubmed-article:2480380 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:2480380 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:2480380 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:2480380 | lifeskim:mentions | umls-concept:C1415993 | lld:lifeskim |
| pubmed-article:2480380 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:2480380 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2480380 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:2480380 | pubmed:dateCreated | 1990-1-19 | lld:pubmed |
| pubmed-article:2480380 | pubmed:abstractText | We have established an Ag-specific in vitro system for studying the roles of Ag and IL-5 in B cell differentiation and Ig production. The murine B cell leukemia, BCL1B1, was transfected with mu and kappa genomic sequences and VS107 V regions that conferred a T15 Id and phosphocholine-binding specificity upon the cells. Transfected cells were treated with both the T-dependent Ag phosphorylcholine-key-hole limpet hemocyanin (PC-KLH), and 0.5 ng/ml purified IL-5. After 3.5 days steady state mu-mRNA levels increased three- to fourfold over mu-mRNA levels obtained from untreated cultures, or cultures treated with IL-5 or PC-KLH alone. IL-5 alone caused increased Ig secretion and a nearly twofold increase in proliferation. Additionally, cells treated with PC-KLH alone were able to process the Ag and present it to T cells as shown by subsequent lymphokine production. Thus, both Ag and IL-5 used singly appear to interact with their respective receptors, although neither Ag nor IL-5 increased mu-mRNA levels when used singly. The production of increased mu-mRNA levels obtained with Ag plus IL-5 required polymerase II transcription, suggesting that they may act to increase Ig transcription directly. | lld:pubmed |
| pubmed-article:2480380 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2480380 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2480380 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2480380 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2480380 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2480380 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2480380 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:2480380 | pubmed:author | pubmed-author:TuckerP WPW | lld:pubmed |
| pubmed-article:2480380 | pubmed:author | pubmed-author:CoffmanR LRL | lld:pubmed |
| pubmed-article:2480380 | pubmed:author | pubmed-author:DaiYY | lld:pubmed |
| pubmed-article:2480380 | pubmed:author | pubmed-author:WebbC FCF | lld:pubmed |
| pubmed-article:2480380 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2480380 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:2480380 | pubmed:volume | 143 | lld:pubmed |
| pubmed-article:2480380 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2480380 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2480380 | pubmed:pagination | 3934-9 | lld:pubmed |
| pubmed-article:2480380 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:2480380 | pubmed:meshHeading | pubmed-meshheading:2480380-... | lld:pubmed |
| pubmed-article:2480380 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2480380 | pubmed:articleTitle | Induction of immunoglobulin mu mRNA in a B cell transfectant stimulated with interleukin-5 and a T-dependent antigen. | lld:pubmed |
| pubmed-article:2480380 | pubmed:affiliation | Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235. | lld:pubmed |
| pubmed-article:2480380 | pubmed:publicationType | Journal Article | lld:pubmed |
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