Linked Life Data

2479799

Source:http://linkedlifedata.com/resource/pubmed/id/2479799

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-12-28
pubmed:abstractText
A novel conditioned place preference (CPP) method is described. The behavioral testing apparatus is a circular open field consisting of 4 uniform quadrants that are equally preferred by the rats prior to drug treatment. In an illustrative experiment, rats received an i.p. injection of either morphine (10 mg/kg), substance P (50 micrograms/kg) or vehicle (phosphate-buffered 0.01 M acetic acid in saline) on 3 consecutive days and were placed into their assigned treatment quadrant. Four animals were simultaneously treated with the aid of barriers, which restricted each rat to its treatment quadrant. On the test for CPPs, when provided a choice between the 4 quadrants, rats treated with morphine and substance P exhibited preferences for the quadrant which had been paired with the drugs, illustrating the usefulness of this procedure for assessing the reinforcing properties of the two drugs. Gross locomotor activity was not influenced by either treatment. The advantages of this version of the CPP method over the conventional shuttle-box procedures are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0165-0270
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
141-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Conditioned place preference in the corral: a procedure for measuring reinforcing properties of drugs.
pubmed:affiliation
Institute of Physiological Psychology, University of Düsseldorf, F.R.G.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't