Linked Life Data

2479326

Source:http://linkedlifedata.com/resource/pubmed/id/2479326

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-12-8
pubmed:abstractText
An in vitro technique for testing the chemosensitivity of squamous cell carcinoma from the head and neck is described. Single-cell suspensions and tumor slices obtained from human xenografts were used. The sensitivity to cisplatin and bleomycin was quantified using the incorporation of (3H) thymidine as a parameter. The in vitro assays were compared with in vivo tests in mice. No reliable data could be obtained with cell suspensions of these tumors due to a rapid decrease in cell viability during incubation, while tumor slices revealed a stable control level of (3H) thymidine incorporation for up to 30 hours. In 6 out of 7 cases close agreement was found between the effect of the cytotoxic drug on the tissue slices and on the same tumors in nude mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1089-94
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:articleTitle
Cytotoxic drug sensitivity of squamous cell carcinoma as predicted by an in vitro testing model.
pubmed:affiliation
Department of Otorhinolaryngology, University of Nijmegen, The Netherlands.
pubmed:publicationType
Journal Article