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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
1989-11-21
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pubmed:abstractText |
We have made sizeable internal deletions within the self-splicing group I intron of Tetrahymena thermophila. Deletions were made in a piecewise manner in order to remove secondary structural elements thought to be extraneous to the catalytic center of the molecule. The resulting deletion mutants retain self-splicing activity, albeit under modified reaction conditions that enhance duplex stability. Considering those portions of the molecule that can be deleted without a loss of catalytic activity, one is left with a catalytic center of approximately 130 nucleotides that is solely responsible for the molecule's activity.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-11894905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-2421916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-2431151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-2452404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-2456876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-2464798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-2501870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-2579378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-2660003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-2915927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-3014350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-3072259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-3331339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-3422485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-3480510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-3537808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-3647266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-3658691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-3667597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-3697083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-3917861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-4000946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-6186917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-6200938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-6297745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-6354470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-6371808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-6757759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-6817818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2477801-7040372
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7879-89
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1989
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pubmed:articleTitle |
Catalytic activity is retained in the Tetrahymena group I intron despite removal of the large extension of element P5.
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pubmed:affiliation |
Salk Institute for Biological Studies, San Diego, CA 92138.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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