Linked Life Data

2477702

Source:http://linkedlifedata.com/resource/pubmed/id/2477702

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
17
pubmed:dateCreated
1989-11-14
pubmed:abstractText
We evaluated a multicenter cohort of 1219 subjects with hemophilia or related disorders prospectively, focusing on 319 subjects with documented dates of seroconversion to human immunodeficiency virus type 1 (HIV-1). The incidence rate of the acquired immunodeficiency syndrome (AIDS) after seroconversion was 2.67 per 100 person-years and was directly related to age (from 0.83 in persons 1 to 11 years old up to 5.66 in persons 35 to 70 years old; Ptrend = 0.00003). The annual incidence of AIDS ranged from zero during the first year after seroconversion to 7 percent during the eighth year, with eight-year cumulative rates (+/- SE) of 13.3 +/- 5.3 percent for ages 1 to 17, 26.8 +/- 6.4 percent for ages 18 to 34, and 43.7 +/- 16.4 percent for ages 35 to 70. Serial immunologic and virologic markers (total numbers of CD4 lymphocytes, presence of serum interferon or HIV-1 p24 antigen, and low or absent serum levels of anti-p24 or anti-gp120) predicted a high risk for the subsequent development of AIDS. Adults 35 to 70 years old had a higher incidence of low CD4 counts than younger subjects (P less than or equal to 0.005), whereas adolescents had a low rate of anti-p24 loss (P = 0.0007) and subjects 1 to 17 years old had a lower incidence of AIDS after loss of anti-p24 (P = 0.03). These findings not only demonstrate that the risk of AIDS is related directly to age but also suggest that older adults are disproportionately affected during the earlier phases of HIV disease, that adolescents may have a low replication rate of HIV, and that children and adolescents may tolerate severe immunodeficiency better because they have fewer other infections or because of some unmeasured, age-dependent cofactor or immune alteration in the later phase of HIV disease.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0028-4793
pubmed:author
pubmed:issnType
Print
pubmed:day
26
pubmed:volume
321
pubmed:owner
NLM
pubmed:authorsComplete
N
pubmed:pagination
1141-8
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:2477702-Acquired Immunodeficiency Syndrome, pubmed-meshheading:2477702-Adolescent, pubmed-meshheading:2477702-Adult, pubmed-meshheading:2477702-Age Factors, pubmed-meshheading:2477702-Aged, pubmed-meshheading:2477702-Biological Markers, pubmed-meshheading:2477702-CD4-Positive T-Lymphocytes, pubmed-meshheading:2477702-Child, pubmed-meshheading:2477702-Child, Preschool, pubmed-meshheading:2477702-Cohort Studies, pubmed-meshheading:2477702-Drug Contamination, pubmed-meshheading:2477702-Gene Products, gag, pubmed-meshheading:2477702-HIV Antibodies, pubmed-meshheading:2477702-HIV Core Protein p24, pubmed-meshheading:2477702-HIV Envelope Protein gp120, pubmed-meshheading:2477702-HIV Seropositivity, pubmed-meshheading:2477702-Hemophilia A, pubmed-meshheading:2477702-Humans, pubmed-meshheading:2477702-Infant, pubmed-meshheading:2477702-Interferons, pubmed-meshheading:2477702-Middle Aged, pubmed-meshheading:2477702-Multicenter Studies as Topic, pubmed-meshheading:2477702-Prospective Studies, pubmed-meshheading:2477702-Time Factors, pubmed-meshheading:2477702-Viral Core Proteins
pubmed:year
1989
pubmed:articleTitle
A prospective study of human immunodeficiency virus type 1 infection and the development of AIDS in subjects with hemophilia.
pubmed:affiliation
Viral Epidemiology Section, National Cancer Institute, Bethesda, MD 20892.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, U.S. Gov't, P.H.S., Multicenter Study