| pubmed-article:2477002 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2477002 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2477002 | lifeskim:mentions | umls-concept:C1305923 | lld:lifeskim |
| pubmed-article:2477002 | lifeskim:mentions | umls-concept:C0205164 | lld:lifeskim |
| pubmed-article:2477002 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2477002 | pubmed:dateCreated | 1989-11-6 | lld:pubmed |
| pubmed-article:2477002 | pubmed:abstractText | A human SS-A/Ro antigen is present on the polypeptide component of a particle composed of hyRNA and a 60 kD protein. We have now purified the Wil-2 cell 60 kilo dalton (kD) SS-A/Ro protein and determined its amino-terminal amino acid sequence. A synthetic peptide corresponding to residues 7 to 24 of this sequence (RoSP7-24) exhibited enzyme-linked immunosorbent assay (ELISA) binding activity with immunodiffusion-defined, monospecific anti-SS-A/Ro sera. In addition, ELISA binding of monospecific anti-SS-A/Ro sera to native SS-A/Ro antigen was partially inhibited (35%) by KLH-RoSP7-24. Sera from patients known to frequently produce precipitating anti-SS-A/Ro antibody (subacute cutaneous lupus erythematosus [SCLE], 56 patients; Sjögren's syndrome [SS], 41 patients; mothers of infants with neonatal LE [NLE], 10 individuals; infants with congenital heart block [CHB], 5 patients) were tested for reactivity to RoSP7-24 in ELISA. Overall, 38% of SCLE sera, 36% of SS sera, 50% of maternal NLE sera and 20% of CHB infant sera had anti-RoSP7-24 binding levels greater than 2 standard deviations above the mean of that of normal individuals. Of the sera which had anti-SS-A/Ro detected by double immunodiffusion and/or counterimmunoelectrophoresis, 68% of SCLE patients, 71% of SS patients, 55% of NLE mothers and 20% of CHB infants had significantly elevated RoSP7-24 ELISA binding levels. These findings strongly suggest that a major autoepitope of native human SS-A/Ro resides on the amino terminal portion of the Wil-2 SS-A/Ro 60 kD polypeptide.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:2477002 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2477002 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2477002 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2477002 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2477002 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2477002 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2477002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2477002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2477002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2477002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2477002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2477002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2477002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2477002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2477002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2477002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2477002 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2477002 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2477002 | pubmed:issn | 0896-8411 | lld:pubmed |
| pubmed-article:2477002 | pubmed:author | pubmed-author:LeeL ALA | lld:pubmed |
| pubmed-article:2477002 | pubmed:author | pubmed-author:CapraJ DJD | lld:pubmed |
| pubmed-article:2477002 | pubmed:author | pubmed-author:DengJ SJS | lld:pubmed |
| pubmed-article:2477002 | pubmed:author | pubmed-author:ArnettF CFC | lld:pubmed |
| pubmed-article:2477002 | pubmed:author | pubmed-author:NewkirkM MMM | lld:pubmed |
| pubmed-article:2477002 | pubmed:author | pubmed-author:LimaT GTG | lld:pubmed |
| pubmed-article:2477002 | pubmed:author | pubmed-author:SontheimerR... | lld:pubmed |
| pubmed-article:2477002 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2477002 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:2477002 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2477002 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2477002 | pubmed:pagination | 367-74 | lld:pubmed |
| pubmed-article:2477002 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2477002 | pubmed:meshHeading | pubmed-meshheading:2477002-... | lld:pubmed |
| pubmed-article:2477002 | pubmed:meshHeading | pubmed-meshheading:2477002-... | lld:pubmed |
| pubmed-article:2477002 | pubmed:meshHeading | pubmed-meshheading:2477002-... | lld:pubmed |
| pubmed-article:2477002 | pubmed:meshHeading | pubmed-meshheading:2477002-... | lld:pubmed |
| pubmed-article:2477002 | pubmed:meshHeading | pubmed-meshheading:2477002-... | lld:pubmed |
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| pubmed-article:2477002 | pubmed:meshHeading | pubmed-meshheading:2477002-... | lld:pubmed |
| pubmed-article:2477002 | pubmed:meshHeading | pubmed-meshheading:2477002-... | lld:pubmed |
| pubmed-article:2477002 | pubmed:meshHeading | pubmed-meshheading:2477002-... | lld:pubmed |
| pubmed-article:2477002 | pubmed:meshHeading | pubmed-meshheading:2477002-... | lld:pubmed |
| pubmed-article:2477002 | pubmed:meshHeading | pubmed-meshheading:2477002-... | lld:pubmed |
| pubmed-article:2477002 | pubmed:meshHeading | pubmed-meshheading:2477002-... | lld:pubmed |
| pubmed-article:2477002 | pubmed:meshHeading | pubmed-meshheading:2477002-... | lld:pubmed |
| pubmed-article:2477002 | pubmed:meshHeading | pubmed-meshheading:2477002-... | lld:pubmed |
| pubmed-article:2477002 | pubmed:meshHeading | pubmed-meshheading:2477002-... | lld:pubmed |
| pubmed-article:2477002 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2477002 | pubmed:articleTitle | A major autoepitope is present on the amino terminus of a human SS-A/Ro polypeptide. | lld:pubmed |
| pubmed-article:2477002 | pubmed:affiliation | Department of Dermatology, University of Texas Health Science Center, Dallas 75235. | lld:pubmed |
| pubmed-article:2477002 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2477002 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2477002 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2477002 | lld:pubmed |
