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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1989-10-17
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pubmed:abstractText |
Class I major histocompatibility complex proteins appear to be the major cell surface receptors for simian virus 40 (SV40), as implied by the following observations. Adsorption of SV40 to LLC-MK2 rhesus monkey kidney cells specifically inhibited binding of a monoclonal antibody (MAb) against class I human lymphocyte antigen (HLA) proteins. Conversely, pretreatment of LLC-MK2 cells with anti-HLA MAbs inhibited infection by SV40. The ability of anti-HLA to inhibit infection was greatly reduced when the order of addition of the anti-HLA and the virus was reversed. Infection was also inhibited by preincubating SV40 with purified soluble class I protein. Finally, human lymphoblastoid cells of the Daudi line, which do not express class I major histocompatibility complex proteins, were infected at relatively low levels with SV40 virions. In a control experiment, we found that pretreatment of cells with a MAb specific for the leukocytic-function-associated antigen LFA-3 actually enhanced infection. This finding may also support the premise that class I major histocompatibility complex proteins are receptors for SV40.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-11894933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-13774265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-176470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-219235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-2536142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-2536822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-2538240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-2538243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-2538244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-2538245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-2541915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-2823150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-2827378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-2835857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-2840661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-2993920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-3263576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-3289571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-3309949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-3374584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-6083454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-6096719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-6187124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-6255675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-6298589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-6313808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-6345670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2476575-92183
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD58,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class I,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Virus
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4474-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2476575-Antibodies, Monoclonal,
pubmed-meshheading:2476575-Antigens, CD58,
pubmed-meshheading:2476575-Antigens, Surface,
pubmed-meshheading:2476575-Histocompatibility Antigens Class I,
pubmed-meshheading:2476575-Humans,
pubmed-meshheading:2476575-Immunoglobulins,
pubmed-meshheading:2476575-Membrane Glycoproteins,
pubmed-meshheading:2476575-Receptors, Virus,
pubmed-meshheading:2476575-Simian virus 40
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pubmed:year |
1989
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pubmed:articleTitle |
Class I major histocompatibility proteins as cell surface receptors for simian virus 40.
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pubmed:affiliation |
Graduate Program in Neuroscience and Behavior, University of Massachusetts, Amhers 01003.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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