Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1989-10-20
|
| pubmed:abstractText |
We determined serum CK-BB mass concentration using a specific RIA method, in 267 patients with carcinoma confirmed histologically distributed as follows: 46 prostatic adenocarcinoma, 52 lung neoplasies, 70 colon carcinoma, 52 breast carcinoma and 41 gastric carcinoma; and also in 135 patients with histologically proved non-neoplastic diseases distributed as follows: 28 prostatic hyperplasy, 31 lung tuberculosis, 29 inflammatory bowel disease, 27 fibrocystic mastopathy and 20 gastroduodenal ulcer. Reference values in healthy subjects (n = 360) were 5.46 +/- 2.68 (SD) ng/ml. We found that serum CK-BB mass concentration is not a specific tumor marker but it is a valuable indicator of responsing to therapy and metastatic widespread. However, in prostatic carcinoma--prevalence 0.25, predictive positive value (PPV) 0.51 and predictive negative value (PNV) 0.88--and breast carcinoma--prevalence 0.32, PPV 0.60 and PNV 0.87--serum CK-BB can be used as a tumor marker. Only 12 over 268 patients with different neoplastic disease (4.47%) showed detectable serum CK-BB catalytic concentrations.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0009-8981
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
30
|
| pubmed:volume |
182
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
183-93
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2476265-Adult,
pubmed-meshheading:2476265-Aged,
pubmed-meshheading:2476265-Breast Neoplasms,
pubmed-meshheading:2476265-Colonic Neoplasms,
pubmed-meshheading:2476265-Creatine Kinase,
pubmed-meshheading:2476265-Fibrocystic Breast Disease,
pubmed-meshheading:2476265-Humans,
pubmed-meshheading:2476265-Inflammatory Bowel Diseases,
pubmed-meshheading:2476265-Isoenzymes,
pubmed-meshheading:2476265-Lung Neoplasms,
pubmed-meshheading:2476265-Male,
pubmed-meshheading:2476265-Middle Aged,
pubmed-meshheading:2476265-Peptic Ulcer,
pubmed-meshheading:2476265-Prostatic Hyperplasia,
pubmed-meshheading:2476265-Prostatic Neoplasms,
pubmed-meshheading:2476265-Stomach Neoplasms,
pubmed-meshheading:2476265-Tuberculosis, Pulmonary,
pubmed-meshheading:2476265-Tumor Markers, Biological
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Serum CK-BB as a tumor marker in patients with carcinoma confirmed histologically.
|
| pubmed:affiliation |
Servicio de Bioquímica, Hospital 12 de Octubre, Madrid, Spain.
|
| pubmed:publicationType |
Journal Article
|