Linked Life Data

2475835

Source:http://linkedlifedata.com/resource/pubmed/id/2475835

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-9-29
pubmed:abstractText
The effect of lindane on 45Ca fluxes in synaptosomes was examined to determine whether modulation of calcium regulation can explain the lindane-induced enhancement in neurotransmitter release observed in other preparations. Lindane (0.03 - 4.6 microM) enhanced calcium uptake in non-depolarizing (low K+) medium: the effect was maximal at 0.1 microM lindane, which increased uptake by 15.8%. Lindane (11.5 microM) decreased calcium uptake in depolarizing (high K+) medium; lower concentrations were ineffective. In addition, lindane (9.2 microM) increased early 45Ca release from synaptosomes. However, lindane (2.4 or 5.9 microM) had no effect on calcium uptake by lysed synaptosomes in the presence or absence of mitochondrial poisons and/or ATP, indicating that lindane does not affect sub-cellular calcium storage. It is concluded that the lindane-induced changes in synaptosomal calcium flux are due to an increase in non-specific synaptic membrane permeability to calcium.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0161-813X
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
29-39
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Effects of lindane on calcium fluxes in synaptosomes.
pubmed:affiliation
Department of Environmental Toxicology, University of California, Davis 95616.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't