Linked Life Data

2475620

Source:http://linkedlifedata.com/resource/pubmed/id/2475620

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1989-10-12
pubmed:abstractText
The incidence and distribution of keratinocytes expressing the major histocompatability complex antigens HLA DR, DP and DQ and their relationship to the density of the inflammatory infiltrate was determined in lesions of oral lichen planus and normal mucosa using an immunoalkaline phosphatase technique. Seven of eight biopsies of lichen planus showed evidence of keratinocyte HLA DR expression but the pattern was variable both within and between biopsies. A significant increase in density of lymphocytes was found beneath those areas showing HLA DR expression throughout the prickle cell layer compared with those areas showing patchy or no expression. No evidence for keratinocyte expression of HLA DP or DQ was found. These results suggest that expression of HLA DR by keratinocytes in lichen planus may be induced by the lymphocytic infiltrate perhaps as a result of interferon gamma production. The functional significance of such MHC Class II expression remains unknown.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0904-2512
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
305-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Expression of MHC class II antigens (HLA DR, DP and DQ) by keratinocytes in oral lichen planus.
pubmed:affiliation
Department of Oral Pathology, London Hospital Medical College, England, UK.
pubmed:publicationType
Journal Article