Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1989-9-21
pubmed:abstractText
A novel stage in early B-lymphocyte differentiation has been identified in normal mouse bone marrow cells. Earlier work had demonstrated that bone marrow cells characterized by low levels of Thy-1 and lack of a panel of lineage markers (Thy-1lo Lin- cells) were highly enriched for pluripotent hematopoietic stem cells. In this paper, we present evidence that another bone marrow population, which expressed low levels of Thy-1 and coexpressed B220, a B-lineage-specific form of the leukocyte common antigen, contained early and potent precursors for B lymphocytes upon in vivo transfer to irradiated hosts. These Thy-1lo B220+ cells, comprising 1 to 2% of bone marrow cells, were enriched for large cells in the mitotic cycle; the population lacked significant pluripotent hematopoietic stem cell activity and myeloid-erythroid progenitors. Most strikingly, Thy-1lo B220+ cells represented a highly enriched population of bone marrow cells that could be targets of Abelson murine leukemia virus transformation. We propose that Thy-1lo B220+ bone marrow cells represent the earliest stage of committed lymphocyte progenitors, intermediate in differentiation between Thy-1lo Lin- pluripotent stem cells and, in the B lineage, Thy-1- B220+ pre-B cells.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-1195397, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-13776896, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-163444, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-168584, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-178822, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-212198, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-2436035, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-2577321, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-2868799, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-2895825, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-2896758, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-2898810, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-2997360, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-3081433, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-3096879, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-311896, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-3260264, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-3493849, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-398327, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-4141645, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-4318922, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-567555, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-6086308, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-6124000, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-6124427, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-6142077, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-6246448, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-6264446, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-6276010, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-6277505, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-6303705, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-6312838, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-6336590, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-6611551, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-6970340, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-6973478, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-6983999, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-6984001, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-7388941, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-814466, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-87465, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-89034, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-8927055, http://linkedlifedata.com/resource/pubmed/commentcorrection/2474759-96180
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0270-7306
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2665-71
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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