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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1989-9-19
|
| pubmed:abstractText |
Human T lymphotropic virus type I (HTLV-I) was isolated from peripheral blood- and cerebrospinal fluid-derived mononuclear cells of a 13-y-old boy and from the peripheral blood lymphocytes of both his parents. All three had IgG antibodies to HTLV-I and varying degrees of the clinical features of tropical spastic paraparesis (TSP). The son also had IgM antibodies specific for HTLV-I in his serum. Isolations were successfully made from peripheral blood lymphocytes and cerebrospinal fluid lymphocytes stimulated with interleukin-2 or cocultivated with umbilical cord blood mononuclear cells. Established cell lines contained HTLV-I antigen by immunfluorescence and cell-associated virus by electron microscopy; cells became transformed in vitro as determined by their continuous growth in the absence of exogenous interleukin-2. This boy is the youngest TSP patient known to be reported, and the isolation of HTLV-I from all three family members suggests the causative role of this virus in TSP.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0022-1899
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
160
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
371-9
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2474617-Adult,
pubmed-meshheading:2474617-Cell Division,
pubmed-meshheading:2474617-Cells, Cultured,
pubmed-meshheading:2474617-Child,
pubmed-meshheading:2474617-Child, Preschool,
pubmed-meshheading:2474617-Family,
pubmed-meshheading:2474617-Female,
pubmed-meshheading:2474617-Fetal Blood,
pubmed-meshheading:2474617-Fluorescent Antibody Technique,
pubmed-meshheading:2474617-HTLV-I Antigens,
pubmed-meshheading:2474617-Human T-lymphotropic virus 1,
pubmed-meshheading:2474617-Humans,
pubmed-meshheading:2474617-Interleukin-2,
pubmed-meshheading:2474617-Lymphocytes,
pubmed-meshheading:2474617-Male,
pubmed-meshheading:2474617-Microscopy, Electron,
pubmed-meshheading:2474617-Middle Aged,
pubmed-meshheading:2474617-Paraparesis, Tropical Spastic,
pubmed-meshheading:2474617-Pregnancy,
pubmed-meshheading:2474617-RNA-Directed DNA Polymerase
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Isolation and characterization of HTLV-I from symptomatic family members with tropical spastic paraparesis (HTLV-I encephalomyeloneuropathy).
|
| pubmed:affiliation |
Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.
|
| pubmed:publicationType |
Journal Article,
Case Reports
|