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rdf:type |
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lifeskim:mentions |
umls-concept:C0003242,
umls-concept:C0008051,
umls-concept:C0013739,
umls-concept:C0020964,
umls-concept:C0030498,
umls-concept:C0332157,
umls-concept:C0871261,
umls-concept:C1314939,
umls-concept:C1704632,
umls-concept:C1705920,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
9
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pubmed:dateCreated |
1989-9-15
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pubmed:abstractText |
Polyclonal anti-idiotype 1073 (anti-Id 1073), raised against a monoclonal antibody specific for the protective epitope(s) of Eimeria tenella sporozoites, induced cell-mediated immune (CMI) responses in bursectomized chickens. Whereas alhydrogel-adsorbed anti-Id 1073 was sufficient to engender the CMI response at 4 h after injection, induction of the CMI response at 24 h required both alhydrogel and muramyl dipeptide sterol. Exposure of immunized chickens to live parasites prompted a dichotomous effect on the CMI response engendered by anti-Id in that the 4-h CMI response was preferentially stimulated and the 24-h CMI response was down regulated. Both types of CMI response were transferable to naive chickens by T cells from anti-Id 1073 immune donors or by parasite-specific T cells from clones 21 and 27. These T-cell clones were generated from chickens immunized by repeated infections with E. tenella and showed in vitro proliferative responses to anti-Id 1073. The abilities of T cells from clone 21 to selectively transfer the 4-h CMI response and to generate gamma interferon to activate macrophages for their cytotoxic effects on Eimeria sporozoites correlate with the preferential stimulation by parasites of the 4-h CMI response in chickens immunized with anti-Id 1073. These data show that anti-Id 1073 mimics the protective epitope(s) of the parasite and primes chickens for protective CMI responses. Cytotoxic T cells, equivalent to the mammalian T-cell subset of the Lyt2+ phenotype, appear to be the primary effector T cells in the CMI response engendered by anti-Id 1073 against Eimeria parasites.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-11993330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-2419430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-2427223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-2535856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-2580906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-2783604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-2798467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-2798468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-2898430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-2945866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-2950059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-2953788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-2960943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-303775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-3084645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-3085218,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-3112230,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-3131421,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-3258583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-3259601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-3496277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-3548029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-3920148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-3926895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-4010784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-4142565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-5459870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-6206183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-6326148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-6332875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-6376788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-6384416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-6403361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-6415111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-6445395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-6505692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-6603657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-6607967,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-7019374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-7086136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-7097160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-76579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474502-91656
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2804-10
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2474502-Animals,
pubmed-meshheading:2474502-Antibodies, Anti-Idiotypic,
pubmed-meshheading:2474502-Antigens, Protozoan,
pubmed-meshheading:2474502-Chickens,
pubmed-meshheading:2474502-Coccidiosis,
pubmed-meshheading:2474502-Epitopes,
pubmed-meshheading:2474502-Hypersensitivity, Delayed,
pubmed-meshheading:2474502-Immunity, Cellular,
pubmed-meshheading:2474502-Immunization, Passive,
pubmed-meshheading:2474502-Immunoglobulin Idiotypes,
pubmed-meshheading:2474502-Kinetics,
pubmed-meshheading:2474502-T-Lymphocytes
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pubmed:year |
1989
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pubmed:articleTitle |
Parasite exposure elicits a preferential T-cell response involved in protective immunity against Eimeria species in chickens primed by an internal-image anti-idiotypic antibody.
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