Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1989-8-29
|
| pubmed:abstractText |
This 10-year follow-up study of 91 patients with disseminated testicular nonseminomatous cancer, treated with cisplatin, vinblastine, and bleomycin (PVB) induction chemotherapy and vinblastine plus bleomycin maintenance chemotherapy for a planned period of 2 years, shows a 63% cure rate. The predominant long-term sequelae are neurological and sexual dysfunction in 68% and 40% of patients, respectively. Two patients died of myocardial infarction. Sixteen percent of patients developed hypertension, 23% Raynaud's phenomenon, and 25% ototoxicity. Despite the long-term side effects, 90% of the patients who responded to a questionnaire are fully employed. This study shows that the maintenance chemotherapy has contributed to the incidence and/or degree of neurotoxicity, hypertension, and renal function disturbance.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0732-183X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
7
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1099-104
|
| pubmed:dateRevised |
2006-4-24
|
| pubmed:meshHeading |
pubmed-meshheading:2474060-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:2474060-Bleomycin,
pubmed-meshheading:2474060-Cisplatin,
pubmed-meshheading:2474060-Creatinine,
pubmed-meshheading:2474060-Employment,
pubmed-meshheading:2474060-Follow-Up Studies,
pubmed-meshheading:2474060-Humans,
pubmed-meshheading:2474060-Hypertension,
pubmed-meshheading:2474060-Kidney,
pubmed-meshheading:2474060-Male,
pubmed-meshheading:2474060-Middle Aged,
pubmed-meshheading:2474060-Neoplasm Recurrence, Local,
pubmed-meshheading:2474060-Physical Fitness,
pubmed-meshheading:2474060-Prognosis,
pubmed-meshheading:2474060-Raynaud Disease,
pubmed-meshheading:2474060-Sexual Behavior,
pubmed-meshheading:2474060-Testicular Neoplasms,
pubmed-meshheading:2474060-Vinblastine
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Ten-year survival and late sequelae in testicular cancer patients treated with cisplatin, vinblastine, and bleomycin.
|
| pubmed:affiliation |
Free University Hospital, Amsterdam, The Netherlands.
|
| pubmed:publicationType |
Journal Article
|