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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1989-9-5
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pubmed:abstractText |
The major encephalitogenic epitope for Lewis rats is the 72-89 sequence of guinea pig basic protein (GP-BP) or rat basic protein (Rt-BP). T cells responsive to this epitope are I-A restricted and preferentially express the V alpha 2:V beta 8 gene combination in their TCR. In this work, we describe for the first time the delayed appearance of T cells specific for additional discrete determinant of BP, the nonencephalitogenic 55-68 sequence of GP-BP restricted by I-A, and the encephalitogenic 87-99 sequence of Rt-BP restricted by I-E. The TCR V alpha 2:V beta 8 gene combination was expressed by both encephalitogenic GP-BP S72-89 and Rt-BP S87-99 T cell specificities but not by GP-BP 44-68-specific T cells. This is the first demonstration of I-E-restricted encephalitogenic T cells in Lewis rats and supports the conclusion that the I-E class II locus is involved in autoimmune diseases.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474052-2410448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474052-2428509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474052-2430104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474052-2431317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474052-2435001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474052-2442405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474052-2456304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474052-2459291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474052-2460551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474052-2467920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474052-2468787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474052-2579140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474052-2582032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474052-2582033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474052-3043226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474052-3876513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474052-4142443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474052-5096093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2474052-64589
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
170
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
355-67
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2474052-Amino Acid Sequence,
pubmed-meshheading:2474052-Animals,
pubmed-meshheading:2474052-Clone Cells,
pubmed-meshheading:2474052-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:2474052-Epitopes,
pubmed-meshheading:2474052-Histocompatibility Antigens Class II,
pubmed-meshheading:2474052-Hypersensitivity, Delayed,
pubmed-meshheading:2474052-Immunologic Memory,
pubmed-meshheading:2474052-Molecular Sequence Data,
pubmed-meshheading:2474052-Myelin Basic Proteins,
pubmed-meshheading:2474052-Rats,
pubmed-meshheading:2474052-Rats, Inbred Lew,
pubmed-meshheading:2474052-T-Lymphocytes,
pubmed-meshheading:2474052-Time Factors
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pubmed:year |
1989
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pubmed:articleTitle |
T cell determinants of myelin basic protein include a unique encephalitogenic I-E-restricted epitope for Lewis rats.
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pubmed:affiliation |
Veterans Administration Medical Center, Portland, Oregon 97201.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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