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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1989-8-30
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pubmed:abstractText |
In the present study the clearance kinetics and tissue distribution of human polyclonal heat-aggregated serum IgA (AIgA) of different sizes in rats was studied after intravenous administration of 125I-AIgA. The 125I-AIgA of different sizes disappeared from the circulation in a biphasic manner with an initial rapid half-life (T1/2) and a second slower T1/2. The first T1/2 was related to the size of the 125I-AIgA: high molecular weight (MW) 125I-AIgA was cleared much faster than 125I-AIgA with a low MW. Relatively more degradation products were observed in blood when high MW 125I-AIgA were injected as compared to low MW 125I-AIgA. The AIgA were mainly taken up by the liver. Eight minutes after injection of high MW 125I-AIgA, 90% of the injected dose was found in the liver, whereas less than 2% was detected in the spleen. Very little activity was detectable in other organs, such as lungs, heart and kidneys. In the present study 1-3% of the injected 125I-AIgA were found in the bile. Analysis of this material revealed that low MW 125I-AIgA were transported more efficiently to the bile than high MW 125I-AIgA. To obtain more insight into the receptors involved in the clearance of 125I-AIgA, rats were pretreated with ovalbumin or asialofetuin. The clearance of 125I-AIgA of different sizes was inhibited when rats were pretreated with asialofetuin. Pretreatment with ovalbumin had no effect on the clearance rates of 125I-AIgA. These results suggest a role for carbohydrate receptors, which recognize glycoprotein-containing galactose terminal residues on Kupffer cells, in the clearance of 125I-AIgA.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-274729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-287039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-3169844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-3173354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-3296685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-3338646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-3518747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-3569402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-3576132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-366735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-3701070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-3743631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-3949883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-4065823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-4850305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-512590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-512591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-6219575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-6287920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-6292896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-6467681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-6504051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-6715019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-6736868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-6778920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-6833754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-6932039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-7005033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-7044634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-7061858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-7096566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-7146826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-7251055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-7391051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-7446551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-7450685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-7461726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-915301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-94694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2473956-95955
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
274-80
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:2473956-Animals,
pubmed-meshheading:2473956-Asialoglycoproteins,
pubmed-meshheading:2473956-Binding, Competitive,
pubmed-meshheading:2473956-Fetuins,
pubmed-meshheading:2473956-Humans,
pubmed-meshheading:2473956-Immunoglobulin A,
pubmed-meshheading:2473956-Injections, Intravenous,
pubmed-meshheading:2473956-Liver,
pubmed-meshheading:2473956-Macromolecular Substances,
pubmed-meshheading:2473956-Male,
pubmed-meshheading:2473956-Metabolic Clearance Rate,
pubmed-meshheading:2473956-Molecular Weight,
pubmed-meshheading:2473956-Ovalbumin,
pubmed-meshheading:2473956-Rats,
pubmed-meshheading:2473956-Rats, Inbred Strains,
pubmed-meshheading:2473956-Sodium Chloride,
pubmed-meshheading:2473956-Tissue Distribution,
pubmed-meshheading:2473956-alpha-Fetoproteins
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pubmed:year |
1989
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pubmed:articleTitle |
Clearance kinetics and tissue distribution of aggregated human serum IgA in rats.
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pubmed:affiliation |
Department of Nephrology, University Hospital, Leiden, The Netherlands.
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