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pubmed-article:2473304pubmed:abstractTextThe vasoconstricting action of endothelin-1 (ET-1) is partly mediated by voltage-dependent L-type Ca2+ channels. Activation of the Ca2+ channels is indirect. ET-1 action involves (i) the hydrolysis of phosphatidylinositol and the release of Ca2+ from internal stores and (ii) the opening of a nonselective cation channel in the plasma membrane. The resulting depolarization triggers the activity of L-type Ca2+ channels.lld:pubmed
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pubmed-article:2473304pubmed:articleTitleMolecular mechanism of endothelin-1 action on aortic cells.lld:pubmed
pubmed-article:2473304pubmed:affiliationCentre de Biochimie du Centre National de la Recherche Scientifique, Nice, France.lld:pubmed
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