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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1989-8-21
|
| pubmed:abstractText |
The vasoconstricting action of endothelin-1 (ET-1) is partly mediated by voltage-dependent L-type Ca2+ channels. Activation of the Ca2+ channels is indirect. ET-1 action involves (i) the hydrolysis of phosphatidylinositol and the release of Ca2+ from internal stores and (ii) the opening of a nonselective cation channel in the plasma membrane. The resulting depolarization triggers the activity of L-type Ca2+ channels.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0160-2446
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13 Suppl 5
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
S186-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2473304-Animals,
pubmed-meshheading:2473304-Aorta,
pubmed-meshheading:2473304-Calcium,
pubmed-meshheading:2473304-Calcium Channels,
pubmed-meshheading:2473304-Electrophysiology,
pubmed-meshheading:2473304-Endothelins,
pubmed-meshheading:2473304-Peptides,
pubmed-meshheading:2473304-Rats
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Molecular mechanism of endothelin-1 action on aortic cells.
|
| pubmed:affiliation |
Centre de Biochimie du Centre National de la Recherche Scientifique, Nice, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|