| pubmed-article:2471779 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2471779 | lifeskim:mentions | umls-concept:C0040113 | lld:lifeskim |
| pubmed-article:2471779 | lifeskim:mentions | umls-concept:C0206431 | lld:lifeskim |
| pubmed-article:2471779 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:2471779 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:2471779 | lifeskim:mentions | umls-concept:C1524075 | lld:lifeskim |
| pubmed-article:2471779 | lifeskim:mentions | umls-concept:C1704419 | lld:lifeskim |
| pubmed-article:2471779 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:2471779 | lifeskim:mentions | umls-concept:C2697616 | lld:lifeskim |
| pubmed-article:2471779 | lifeskim:mentions | umls-concept:C0386280 | lld:lifeskim |
| pubmed-article:2471779 | lifeskim:mentions | umls-concept:C0619541 | lld:lifeskim |
| pubmed-article:2471779 | lifeskim:mentions | umls-concept:C0621732 | lld:lifeskim |
| pubmed-article:2471779 | lifeskim:mentions | umls-concept:C0621734 | lld:lifeskim |
| pubmed-article:2471779 | lifeskim:mentions | umls-concept:C0337112 | lld:lifeskim |
| pubmed-article:2471779 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2471779 | pubmed:dateCreated | 1989-7-19 | lld:pubmed |
| pubmed-article:2471779 | pubmed:abstractText | The B chain of mammalian insulins contains appropriately spaced amino acids that predict recognition by T cells. However, all T cell clones from an HLA-DR1, Dw6 diabetic donor recognize epitopes associated with the A chain, and the B chain was found to inhibit these responses. Effective intramolecular competition at the level of the APC, not a direct effect on the T cell, is responsible for the inhibition. Insulin B chain contains two clusters of amino acid homology with the TCR beta chain and B chain peptides lacking these clusters do not compete for antigen presentation. A hole in the repertoire for T cells that recognize this portion of the insulin molecule may arise in the thymus by deletion of T cells that recognize similar peptides. | lld:pubmed |
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| pubmed-article:2471779 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2471779 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2471779 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2471779 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2471779 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2471779 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2471779 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:2471779 | pubmed:author | pubmed-author:ThomasJ WJW | lld:pubmed |
| pubmed-article:2471779 | pubmed:author | pubmed-author:MillerG GGG | lld:pubmed |
| pubmed-article:2471779 | pubmed:author | pubmed-author:DayG WGW | lld:pubmed |
| pubmed-article:2471779 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2471779 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2471779 | pubmed:volume | 169 | lld:pubmed |
| pubmed-article:2471779 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2471779 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2471779 | pubmed:pagination | 2251-6 | lld:pubmed |
| pubmed-article:2471779 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:2471779 | pubmed:meshHeading | pubmed-meshheading:2471779-... | lld:pubmed |
| pubmed-article:2471779 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2471779 | pubmed:articleTitle | Insulin B chain functions as an effective competitor of antigen presentation via peptide homologies present in the thymus. | lld:pubmed |
| pubmed-article:2471779 | pubmed:affiliation | Department of Medicine, Baylor College of Medicine, Houston, Texas 77030. | lld:pubmed |
| pubmed-article:2471779 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2471779 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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