Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1989-7-19
pubmed:abstractText
The B chain of mammalian insulins contains appropriately spaced amino acids that predict recognition by T cells. However, all T cell clones from an HLA-DR1, Dw6 diabetic donor recognize epitopes associated with the A chain, and the B chain was found to inhibit these responses. Effective intramolecular competition at the level of the APC, not a direct effect on the T cell, is responsible for the inhibition. Insulin B chain contains two clusters of amino acid homology with the TCR beta chain and B chain peptides lacking these clusters do not compete for antigen presentation. A hole in the repertoire for T cells that recognize this portion of the insulin molecule may arise in the thymus by deletion of T cells that recognize similar peptides.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2471779-2414111, http://linkedlifedata.com/resource/pubmed/commentcorrection/2471779-2433769, http://linkedlifedata.com/resource/pubmed/commentcorrection/2471779-2435001, http://linkedlifedata.com/resource/pubmed/commentcorrection/2471779-2443855, http://linkedlifedata.com/resource/pubmed/commentcorrection/2471779-2445817, http://linkedlifedata.com/resource/pubmed/commentcorrection/2471779-2447156, http://linkedlifedata.com/resource/pubmed/commentcorrection/2471779-2451692, http://linkedlifedata.com/resource/pubmed/commentcorrection/2471779-2460529, http://linkedlifedata.com/resource/pubmed/commentcorrection/2471779-2963699, http://linkedlifedata.com/resource/pubmed/commentcorrection/2471779-3075590, http://linkedlifedata.com/resource/pubmed/commentcorrection/2471779-3261393, http://linkedlifedata.com/resource/pubmed/commentcorrection/2471779-3459185, http://linkedlifedata.com/resource/pubmed/commentcorrection/2471779-3490919, http://linkedlifedata.com/resource/pubmed/commentcorrection/2471779-3494522, http://linkedlifedata.com/resource/pubmed/commentcorrection/2471779-6161958, http://linkedlifedata.com/resource/pubmed/commentcorrection/2471779-6795263
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
169
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2251-6
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Insulin B chain functions as an effective competitor of antigen presentation via peptide homologies present in the thymus.
pubmed:affiliation
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.