Linked Life Data

2471114

Source:http://linkedlifedata.com/resource/pubmed/id/2471114

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-7-7
pubmed:abstractText
Pressure ejection of serotonin (2 x 10(-4) M) onto dentate granule neurons in vitro produced a short-lasting membrane hyperpolarization associated with a 10-30% decrease in the input resistance. The hyperpolarization magnitude depended on the extracellular K+ concentration but not on the extra or intracellular Ca2+ concentration. It was followed by a depolarization, especially when serotonin was applied onto the perisomatic area of the neuron. The post-spike-train afterhyperpolarization, which represents a Ca2+-dependent K+ conductance, was decreased by serotonin by 10-100% and remained reduced for 2-10 min following the serotonin-induced hyperpolarization. Decreased adaptation of cell firing was also observed following serotonin application. Ca2+ action potentials evoked by intracellular depolarizing current pulses in the presence of the Na+ channel blocker tetrodotoxin and the K+ channel blocker tetraethylammonium were followed by a large afterhyperpolarization, which was markedly reduced for several minutes following serotonin application. The preceding Ca2+ action potential was either unaffected or prolonged. The hyperpolarization occurring in response to localized application of serotonin, and the reduction of the afterhyperpolarization, may represent two different mechanisms of serotonin action, probably mediated by different mechanisms. The slow time course of the late depolarization and the afterhyperpolarization depression represent modulatory effects of serotonin on dentate granule neurons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
443-51
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Modulatory actions of serotonin on ionic conductances of hippocampal dentate granule cells.
pubmed:affiliation
Playfair Neuroscience Unit, Toronto Western Hospital, Addiction Research Foundation, Ontario, Canada.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't