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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1989-7-6
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pubmed:abstractText |
Circular strips of the rat gastric corpus muscle were mounted in Krebs solution for isometric tension recording. Addition of capsaicin usually led to either relaxation or contraction, but in some strips a biphasic response was observed. Although no clear-cut concentration-response relationship could be established, capsaicin predominantly induced contraction at 500 nM, whereas at 5 microM it mainly induced relaxation. In Krebs solution containing atropine plus guanethidine, the contraction induced by 500 nM capsaicin was significantly reduced. The contraction induced by capsaicin was abolished by spantide, a tachykinin antagonist, or by tachyphylaxis to substance P. Calcitonin gene-related peptide relaxed gastric smooth muscle, however, a dose-response relationship could not be established. This peptide contracted the muscle strips only at 1 microM. Tachyphylaxis to calcitonin gene-related peptide did not significantly influence the action of capsaicin. Vasoactive intestinal polypeptide dose dependently relaxed gastric corpus strips; however, these responses were qualitatively different from those to capsaicin. It is concluded that capsaicin contracts rat gastric smooth muscle via the release of tachykinins; cholinergic interneurones are involved. The mediator of the capsaicin-induced relaxation has yet to be determined.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcitonin Gene-Related Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Capsaicin,
http://linkedlifedata.com/resource/pubmed/chemical/Dimethylphenylpiperazinium Iodide,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Substance P,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrodotoxin,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoactive Intestinal Peptide
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0014-2999
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
162
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
29-36
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2470602-Animals,
pubmed-meshheading:2470602-Autonomic Nervous System,
pubmed-meshheading:2470602-Calcitonin Gene-Related Peptide,
pubmed-meshheading:2470602-Capsaicin,
pubmed-meshheading:2470602-Dimethylphenylpiperazinium Iodide,
pubmed-meshheading:2470602-Female,
pubmed-meshheading:2470602-Male,
pubmed-meshheading:2470602-Muscle, Smooth,
pubmed-meshheading:2470602-Muscle Contraction,
pubmed-meshheading:2470602-Muscle Relaxation,
pubmed-meshheading:2470602-Neuropeptides,
pubmed-meshheading:2470602-Rats,
pubmed-meshheading:2470602-Rats, Inbred Strains,
pubmed-meshheading:2470602-Stomach,
pubmed-meshheading:2470602-Substance P,
pubmed-meshheading:2470602-Tachyphylaxis,
pubmed-meshheading:2470602-Tetrodotoxin,
pubmed-meshheading:2470602-Vasoactive Intestinal Peptide
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pubmed:year |
1989
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pubmed:articleTitle |
Effect of capsaicin on gastric corpus smooth muscle of the rat in vitro.
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pubmed:affiliation |
Department of Experimental and Clinical Pharmacology, Unversity of Graz, Austria.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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