Linked Life Data

2470304

Source:http://linkedlifedata.com/resource/pubmed/id/2470304

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1989-6-19
pubmed:abstractText
The active participation by keratinocytes (KCs) during cutaneous inflammation involves production of various immunologically active molecules. While interleukin-1 (IL-1) is a well-known KC-derived activator of lymphocytes, less attention has been directed towards characterization of non-PGE KC-derived lymphocyte inhibitory factors. To determine whether transforming growth factor-beta (TGF-beta), which has recently been found to be produced by KCs, may be a biologically important constituent of KC-conditioned medium, we measured the ability of neutralizing antibody of TGF-beta to reverse the inhibitory effect of KC-conditioned medium on mixed lymphocyte reactions (MLR). Not only did exogenously added TGF-beta inhibit the MLR, but KC-conditioned media also inhibited the MLR, and this inhibition was partially reversed using the neutralizing antibody as detected by 3H-thymidine incorporation and phase contrast microscopy. Thus, KC-derived TGF-beta may serve as an important inhibitor of lymphocyte proliferation. These results suggest that the balance of cutaneous immunohomeostasis may involve several different KC-derived factors which may be either lymphocyte activating such as IL-1, or lymphocyte inhibitory such as PGE2 and TGF-beta.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:volume
548
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
312-20
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Keratinocytes produce a lymphocyte inhibitory factor which is partially reversible by an antibody to transforming growth factor-beta.
pubmed:affiliation
Department of Pathology, University of Michigan, Ann Arbor 48109-0602.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.