| pubmed-article:2469911 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2469911 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:2469911 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:2469911 | lifeskim:mentions | umls-concept:C0079459 | lld:lifeskim |
| pubmed-article:2469911 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:2469911 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:2469911 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:2469911 | lifeskim:mentions | umls-concept:C1366463 | lld:lifeskim |
| pubmed-article:2469911 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:2469911 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:2469911 | pubmed:dateCreated | 1989-6-13 | lld:pubmed |
| pubmed-article:2469911 | pubmed:abstractText | Purified recombinant granulocyte colony stimulating factor (G-CSF) and interleukin-6 (IL-6) stimulated the formation of similar numbers of colonies in cultures of normal mouse marrow cells. LIF and IL-6 induced comparable differentiation in clonal cultures of murine M1 leukemic cells and exhibited enhanced actions in combination. However, LIF was 16-25-fold more active than IL-6. Induction of differentiation in M1 leukemic colonies by both LIF and IL-6 was enhanced by the addition of G-CSF or M-CSF but not by GM-CSF or Multi-CSF. Both G-CSF and IL-6, but not LIF, were able to induce differentiation in murine WEHI-3B leukemic colonies, but G-CSF was 10-fold more efficient than IL-6. Both G-CSF and IL-6 were able to stimulate the proliferation of cells of the NFS-60 continuous cell line, but G-CSF was 30-fold more efficient. M1 cells constitutively produced low levels of IL-6 and production was enhanced by LIF, but the general characteristics of the actions of LIF, IL-6, and G-CSF suggested that each operates independently as a direct differentiation inducer of leukemic cells. The similarities in the biology and actions of G-CSF, LIF, and IL-6 suggest that they may be designed to exhibit coordinated biological functions in certain situations. | lld:pubmed |
| pubmed-article:2469911 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2469911 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2469911 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2469911 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2469911 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2469911 | pubmed:month | May | lld:pubmed |
| pubmed-article:2469911 | pubmed:issn | 0887-6924 | lld:pubmed |
| pubmed-article:2469911 | pubmed:author | pubmed-author:MetcalfDD | lld:pubmed |
| pubmed-article:2469911 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2469911 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:2469911 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2469911 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2469911 | pubmed:pagination | 349-55 | lld:pubmed |
| pubmed-article:2469911 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2469911 | pubmed:meshHeading | pubmed-meshheading:2469911-... | lld:pubmed |
| pubmed-article:2469911 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2469911 | pubmed:articleTitle | Actions and interactions of G-CSF, LIF, and IL-6 on normal and leukemic murine cells. | lld:pubmed |
| pubmed-article:2469911 | pubmed:affiliation | Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia. | lld:pubmed |
| pubmed-article:2469911 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2469911 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2469911 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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