Linked Life Data

2469869

Source:http://linkedlifedata.com/resource/pubmed/id/2469869

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1989-6-13
pubmed:abstractText
Smooth muscle cell proliferation is regulated through the coordinated interaction of growth factors/mitogens and growth inhibitors such as heparin. Vascular smooth muscle cells isolated from the thoracic aorta of adult male spontaneously hypertensive rats (SHR) proliferated faster and reached higher cell densities during 8-day culture periods than cells isolated from age- and sex-matched Wistar-Kyoto (WKY) animals. Since both cell isolates were exposed to the same array of growth factors present in fetal calf serum, the differences in proliferation rates were indicative of a differential responsiveness between the two cell types to such factors. Cultures from SHR and WKY rendered quiescent by serum withdrawal were shown to respond to epidermal growth factor in a differential manner, whereas they exhibited similar responsiveness to platelet-derived growth factor and somatomedin C. Cells from hypertensive animals expressed twice as many specific cell surface receptors for epidermal growth factor as their normotensive counterparts. However, in contrast the latter possessed double the number of specific cell surface heparin binding sites when compared to cells from hypertensive animals. The coordinated interaction of heparin epidermal growth factor and extracellular matrix thrombospondin may be a mechanism for vascular smooth muscle growth regulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0160-2446
pubmed:author
pubmed:issnType
Print
pubmed:volume
12 Suppl 5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S124-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Growth regulation in smooth muscle cells from normal and hypertensive rats.
pubmed:affiliation
Department of Research, University Hospital, Basel, Switzerland.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro