| pubmed-article:2469451 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2469451 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:2469451 | lifeskim:mentions | umls-concept:C1708335 | lld:lifeskim |
| pubmed-article:2469451 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:2469451 | lifeskim:mentions | umls-concept:C0020268 | lld:lifeskim |
| pubmed-article:2469451 | lifeskim:mentions | umls-concept:C0032016 | lld:lifeskim |
| pubmed-article:2469451 | lifeskim:mentions | umls-concept:C0025519 | lld:lifeskim |
| pubmed-article:2469451 | lifeskim:mentions | umls-concept:C0026454 | lld:lifeskim |
| pubmed-article:2469451 | lifeskim:mentions | umls-concept:C0066673 | lld:lifeskim |
| pubmed-article:2469451 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:2469451 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2469451 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:2469451 | lifeskim:mentions | umls-concept:C0599682 | lld:lifeskim |
| pubmed-article:2469451 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2469451 | pubmed:dateCreated | 1989-6-22 | lld:pubmed |
| pubmed-article:2469451 | pubmed:abstractText | 1. Single oral doses (100, 200 and 300 mg) of moclobemide, a reversible inhibitor of monoamine oxidase (MAO) with predominant effects on the A-type of the enzyme, were administered to eight young, healthy male volunteers in a double-blind, random-order, placebo-controlled study. The investigation was thereafter continued in an open fashion by administering a single 10 mg dose of the MAO-B inhibitor deprenyl to the same subjects. 2. Deamination of catecholamines was powerfully and dose-dependently inhibited by moclobemide, as evidenced by up to 40% decreases in the urinary excretion of deaminated catecholamine metabolites, corresponding increases in the excretion of non-deaminated, methylated metabolites, and up to 79% average decreases in the plasma concentration of 3,4-dihydroxyphenylglycol (DHPG), a deaminated metabolite of noradrenaline (NA), and up to 75% average decreases in the plasma concentrations of 3,4-dihydroxyphenylacetic acid (DOPAC), a deaminated metabolite of dopamine. The urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA) was only slightly reduced. In contrast, deprenyl, in a dose which almost totally inhibited MAO-B activity in blood platelets, did not appreciably affect the plasma concentrations of DHPG or DOPAC. 3. Due to the rapid, reversible, dose-dependent and MAO-A specific effect of moclobemide on plasma concentrations of DHPG, it is suggested that DHPG in plasma may be a useful indicator of the magnitude and duration of MAO-A inhibition in man. 4. Sympatho-adrenal function at rest was not significantly altered by moclobemide, as judged by unchanged plasma catecholamine concentrations and stable blood pressure and heart rate recordings. 5. Monoamine oxidase type B activity in blood platelets was slightly (less than 30%) and transiently inhibited after moclobemide. 6. The secretion of prolactin was dose-dependently stimulated by moclobemide, whereas the plasma concentrations of growth hormone (hGH) and cortisol remained unchanged. | lld:pubmed |
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| pubmed-article:2469451 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2469451 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2469451 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2469451 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2469451 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2469451 | pubmed:issn | 0306-5251 | lld:pubmed |
| pubmed-article:2469451 | pubmed:author | pubmed-author:KouluMM | lld:pubmed |
| pubmed-article:2469451 | pubmed:author | pubmed-author:PyykköKK | lld:pubmed |
| pubmed-article:2469451 | pubmed:author | pubmed-author:ScheininMM | lld:pubmed |
| pubmed-article:2469451 | pubmed:author | pubmed-author:VuorinenJJ | lld:pubmed |
| pubmed-article:2469451 | pubmed:author | pubmed-author:KallioJJ | lld:pubmed |
| pubmed-article:2469451 | pubmed:author | pubmed-author:ZimmerR HRH | lld:pubmed |
| pubmed-article:2469451 | pubmed:author | pubmed-author:KaarttinenAA | lld:pubmed |
| pubmed-article:2469451 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2469451 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:2469451 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2469451 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2469451 | pubmed:pagination | 243-55 | lld:pubmed |
| pubmed-article:2469451 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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