Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-6-22
pubmed:abstractText
1. Single oral doses (100, 200 and 300 mg) of moclobemide, a reversible inhibitor of monoamine oxidase (MAO) with predominant effects on the A-type of the enzyme, were administered to eight young, healthy male volunteers in a double-blind, random-order, placebo-controlled study. The investigation was thereafter continued in an open fashion by administering a single 10 mg dose of the MAO-B inhibitor deprenyl to the same subjects. 2. Deamination of catecholamines was powerfully and dose-dependently inhibited by moclobemide, as evidenced by up to 40% decreases in the urinary excretion of deaminated catecholamine metabolites, corresponding increases in the excretion of non-deaminated, methylated metabolites, and up to 79% average decreases in the plasma concentration of 3,4-dihydroxyphenylglycol (DHPG), a deaminated metabolite of noradrenaline (NA), and up to 75% average decreases in the plasma concentrations of 3,4-dihydroxyphenylacetic acid (DOPAC), a deaminated metabolite of dopamine. The urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA) was only slightly reduced. In contrast, deprenyl, in a dose which almost totally inhibited MAO-B activity in blood platelets, did not appreciably affect the plasma concentrations of DHPG or DOPAC. 3. Due to the rapid, reversible, dose-dependent and MAO-A specific effect of moclobemide on plasma concentrations of DHPG, it is suggested that DHPG in plasma may be a useful indicator of the magnitude and duration of MAO-A inhibition in man. 4. Sympatho-adrenal function at rest was not significantly altered by moclobemide, as judged by unchanged plasma catecholamine concentrations and stable blood pressure and heart rate recordings. 5. Monoamine oxidase type B activity in blood platelets was slightly (less than 30%) and transiently inhibited after moclobemide. 6. The secretion of prolactin was dose-dependently stimulated by moclobemide, whereas the plasma concentrations of growth hormone (hGH) and cortisol remained unchanged.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-2420928, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-2436247, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-2450251, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-2829953, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-2869509, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-3014595, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-3016787, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-302840, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-3031717, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-3081933, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-3096593, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-3114597, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-3156909, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-3298420, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-3432499, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-3574489, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-3921065, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-4001280, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-4033349, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-4035277, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-4060968, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-5659776, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-603028, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-6098913, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-6178533, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-6247735, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-6382361, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-6388247, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-6429130, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-6463455, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-6628500, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-6639832, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-6703855, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-6735994, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-6791210, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-6812143, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-6874854, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-69882, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-834248, http://linkedlifedata.com/resource/pubmed/commentcorrection/2469451-8682
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/3,4-Dihydroxyphenylacetic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Benzamides, http://linkedlifedata.com/resource/pubmed/chemical/Catecholamines, http://linkedlifedata.com/resource/pubmed/chemical/Epinephrine, http://linkedlifedata.com/resource/pubmed/chemical/Homovanillic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Hydrocortisone, http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyindoleacetic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Methoxyhydroxyphenylglycol, http://linkedlifedata.com/resource/pubmed/chemical/Moclobemide, http://linkedlifedata.com/resource/pubmed/chemical/Monoamine Oxidase, http://linkedlifedata.com/resource/pubmed/chemical/Monoamine Oxidase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine, http://linkedlifedata.com/resource/pubmed/chemical/Pituitary Hormones, Anterior, http://linkedlifedata.com/resource/pubmed/chemical/Selegiline, http://linkedlifedata.com/resource/pubmed/chemical/Vanilmandelic Acid, http://linkedlifedata.com/resource/pubmed/chemical/dihydroxyphenylethylene glycol
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0306-5251
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
243-55
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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