| pubmed-article:2468494 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2468494 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:2468494 | lifeskim:mentions | umls-concept:C0003811 | lld:lifeskim |
| pubmed-article:2468494 | lifeskim:mentions | umls-concept:C0151744 | lld:lifeskim |
| pubmed-article:2468494 | lifeskim:mentions | umls-concept:C0235480 | lld:lifeskim |
| pubmed-article:2468494 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2468494 | lifeskim:mentions | umls-concept:C0205178 | lld:lifeskim |
| pubmed-article:2468494 | lifeskim:mentions | umls-concept:C0032172 | lld:lifeskim |
| pubmed-article:2468494 | lifeskim:mentions | umls-concept:C0243076 | lld:lifeskim |
| pubmed-article:2468494 | lifeskim:mentions | umls-concept:C0035124 | lld:lifeskim |
| pubmed-article:2468494 | lifeskim:mentions | umls-concept:C0279389 | lld:lifeskim |
| pubmed-article:2468494 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2468494 | pubmed:dateCreated | 1989-5-26 | lld:pubmed |
| pubmed-article:2468494 | pubmed:abstractText | The aim of the study was to examine a possible role for platelet activating factor (PAF) in experimental myocardial ischaemia and reperfusion. Anaesthetized open-chest greyhounds were subjected to 40 min of coronary artery (LAD) occlusion followed by reperfusion. Blood samples for platelet counting were obtained from a local coronary vein draining the ischaemic region. Pretreatment with PAF antagonists BN52021 (5 mg kg-1 i.v.) or SRI63441 (10 mg kg-1 i.v.), 15 min prior to occlusion reduced the ventricular ectopic count during the ischaemic period from 614 +/- 82 (controls) to 296 +/- 145 (BN52021) and 474 +/- 200 (SRI63441). Both drugs also reduced the incidence of ventricular fibrillation (VF) (during ischaemia and reperfusion) from 90% (controls), to 50% (BN52021) and 43% (SRI63441). Ischaemia was accompanied by a 32 +/- 7% reduction in coronary venous platelets; this was attenuated by both BN52021 (-2 +/- 6%) and SRI63441) (-1 +/- 5%). These results suggest that PAF may contribute to ischaemia and reperfusion-induced arrhythmias by activating platelets. | lld:pubmed |
| pubmed-article:2468494 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2468494 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2468494 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2468494 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2468494 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2468494 | pubmed:issn | 0195-668X | lld:pubmed |
| pubmed-article:2468494 | pubmed:author | pubmed-author:ParrattJ RJR | lld:pubmed |
| pubmed-article:2468494 | pubmed:author | pubmed-author:BigaudMM | lld:pubmed |
| pubmed-article:2468494 | pubmed:author | pubmed-author:WainwrightC... | lld:pubmed |
| pubmed-article:2468494 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2468494 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:2468494 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2468494 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2468494 | pubmed:pagination | 235-43 | lld:pubmed |
| pubmed-article:2468494 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:2468494 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2468494 | pubmed:articleTitle | The effects of PAF antagonists on arrhythmias and platelets during acute myocardial ischaemia and reperfusion. | lld:pubmed |
| pubmed-article:2468494 | pubmed:affiliation | Department of Physiology and Pharmacology, University of Strathclyde, Glasgow, Scotland, U.K. | lld:pubmed |
| pubmed-article:2468494 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2468494 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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