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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1989-5-26
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pubmed:abstractText |
The aim of the study was to examine a possible role for platelet activating factor (PAF) in experimental myocardial ischaemia and reperfusion. Anaesthetized open-chest greyhounds were subjected to 40 min of coronary artery (LAD) occlusion followed by reperfusion. Blood samples for platelet counting were obtained from a local coronary vein draining the ischaemic region. Pretreatment with PAF antagonists BN52021 (5 mg kg-1 i.v.) or SRI63441 (10 mg kg-1 i.v.), 15 min prior to occlusion reduced the ventricular ectopic count during the ischaemic period from 614 +/- 82 (controls) to 296 +/- 145 (BN52021) and 474 +/- 200 (SRI63441). Both drugs also reduced the incidence of ventricular fibrillation (VF) (during ischaemia and reperfusion) from 90% (controls), to 50% (BN52021) and 43% (SRI63441). Ischaemia was accompanied by a 32 +/- 7% reduction in coronary venous platelets; this was attenuated by both BN52021 (-2 +/- 6%) and SRI63441) (-1 +/- 5%). These results suggest that PAF may contribute to ischaemia and reperfusion-induced arrhythmias by activating platelets.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0195-668X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
235-43
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2468494-Acute Disease,
pubmed-meshheading:2468494-Animals,
pubmed-meshheading:2468494-Blood Gas Analysis,
pubmed-meshheading:2468494-Cardiac Complexes, Premature,
pubmed-meshheading:2468494-Coronary Disease,
pubmed-meshheading:2468494-Disease Models, Animal,
pubmed-meshheading:2468494-Diterpenes,
pubmed-meshheading:2468494-Dogs,
pubmed-meshheading:2468494-Drug Evaluation, Preclinical,
pubmed-meshheading:2468494-Electrocardiography,
pubmed-meshheading:2468494-Ginkgolides,
pubmed-meshheading:2468494-Hemodynamics,
pubmed-meshheading:2468494-Hydrogen-Ion Concentration,
pubmed-meshheading:2468494-Lactones,
pubmed-meshheading:2468494-Myocardial Reperfusion,
pubmed-meshheading:2468494-Oxygen,
pubmed-meshheading:2468494-Platelet Activating Factor,
pubmed-meshheading:2468494-Platelet Count,
pubmed-meshheading:2468494-Quinolinium Compounds,
pubmed-meshheading:2468494-Random Allocation,
pubmed-meshheading:2468494-Tachycardia,
pubmed-meshheading:2468494-Time Factors,
pubmed-meshheading:2468494-Ventricular Fibrillation
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pubmed:year |
1989
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pubmed:articleTitle |
The effects of PAF antagonists on arrhythmias and platelets during acute myocardial ischaemia and reperfusion.
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pubmed:affiliation |
Department of Physiology and Pharmacology, University of Strathclyde, Glasgow, Scotland, U.K.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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