pubmed-article:2468165 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:2468165 | lifeskim:mentions | umls-concept:C0006685 | lld:lifeskim |
pubmed-article:2468165 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
pubmed-article:2468165 | lifeskim:mentions | umls-concept:C0085268 | lld:lifeskim |
pubmed-article:2468165 | pubmed:issue | 8 | lld:pubmed |
pubmed-article:2468165 | pubmed:dateCreated | 1989-5-24 | lld:pubmed |
pubmed-article:2468165 | pubmed:abstractText | An osteoblast calcium channel demonstrated by single channel recordings is associated with calcium antagonist receptor binding sites in osteoblast-like osteosarcoma cells. By using whole cell current recordings we now show that this channel is stimulated by the dihydropyridine calcium agonist drug BAY K 8644. A physiological relevance of these channels is apparent from the stereoselective, potent inhibition of parathyroid hormone-stimulated calcium uptake into osteoblast-like cells in culture by desmethoxyverapamil, a phenylalkylamine calcium antagonist. Secretion by these cells of the bone matrix protein osteocalcin is stimulated by BAY K 8644 and blocked by desmethoxyverapamil and nitrendipine. Evidence for a role of this channel in bone remodeling in intact animals comes from enhanced bone resorption in fetal rat bones observed with BAY K 8644 and stereoselective, potent blockade of resorption by desmethoxyverapamil. | lld:pubmed |
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pubmed-article:2468165 | pubmed:language | eng | lld:pubmed |
pubmed-article:2468165 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:2468165 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:2468165 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:2468165 | pubmed:month | Apr | lld:pubmed |
pubmed-article:2468165 | pubmed:issn | 0027-8424 | lld:pubmed |
pubmed-article:2468165 | pubmed:author | pubmed-author:SnyderS HSH | lld:pubmed |
pubmed-article:2468165 | pubmed:author | pubmed-author:WagnerJ AJA | lld:pubmed |
pubmed-article:2468165 | pubmed:author | pubmed-author:GugginoS ESE | lld:pubmed |
pubmed-article:2468165 | pubmed:author | pubmed-author:LajeunesseDD | lld:pubmed |
pubmed-article:2468165 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:2468165 | pubmed:volume | 86 | lld:pubmed |
pubmed-article:2468165 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:2468165 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:2468165 | pubmed:pagination | 2957-60 | lld:pubmed |
pubmed-article:2468165 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:2468165 | pubmed:year | 1989 | lld:pubmed |
pubmed-article:2468165 | pubmed:articleTitle | Bone remodeling signaled by a dihydropyridine- and phenylalkylamine-sensitive calcium channel. | lld:pubmed |
pubmed-article:2468165 | pubmed:affiliation | Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205. | lld:pubmed |
pubmed-article:2468165 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:2468165 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:2468165 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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